Hypoxic pulmonary vasoconstriction in humans: Tale or myth

Hussain, A.; Suleiman, M. S.; George, S. J.; Loubani, M.; Morice, A.

Abstract

© Hussain et al. Hypoxic Pulmonary vasoconstriction (HPV) describes the physiological adaptive process of lungs to preserves systemic oxygenation. It has clinical implications in the development of pulmonary hypertension which impacts on outcomes of patients undergoing cardiothoracic surgery. This review examines both acute and chronic hypoxic vasoconstriction focusing on the distinct clinical implications and highlights the role of calcium and mitochondria in acute versus the role of reactive oxygen species and Rho GTPases in chronic HPV. Furthermore it identifies gaps of knowledge and need for further research in humans to clearly define this phenomenon and the underlying mechanism.

Citation

Hussain, A., Suleiman, M. S., George, S. J., Loubani, M., & Morice, A. (2017). Hypoxic pulmonary vasoconstriction in humans: Tale or myth. Open Cardiovascular Medicine Journal, 11, 1-13. https://doi.org/10.2174/1874192401711010001

• Journal Article Type: Review
• Acceptance Date: Dec 9, 2016
• Online Publication Date: Jan 24, 2017
• Publication Date: 2017
• Deposit Date: May 10, 2022
• Publicly Available Date: May 23, 2022
• Journal: Open Cardiovascular Medicine Journal
• Electronic ISSN: 1874-1924
• Publisher: Bentham Open
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Pages: 1-13
• DOI: https://doi.org/10.2174/1874192401711010001
• Keywords: Hypoxic Pulmonary Vasoconstriction; Human; Acute hypoxia; Chronic hypoxia; Pulmonary hypertension
• Public URL: https://hull-repository.worktribe.com/output/3601829