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Hypoxic pulmonary vasoconstriction in humans: Tale or myth

Hussain, A.; Suleiman, M. S.; George, S. J.; Loubani, M.; Morice, A.


A. Hussain

M. S. Suleiman

S. J. George

M. Loubani


© Hussain et al. Hypoxic Pulmonary vasoconstriction (HPV) describes the physiological adaptive process of lungs to preserves systemic oxygenation. It has clinical implications in the development of pulmonary hypertension which impacts on outcomes of patients undergoing cardiothoracic surgery. This review examines both acute and chronic hypoxic vasoconstriction focusing on the distinct clinical implications and highlights the role of calcium and mitochondria in acute versus the role of reactive oxygen species and Rho GTPases in chronic HPV. Furthermore it identifies gaps of knowledge and need for further research in humans to clearly define this phenomenon and the underlying mechanism.


Hussain, A., Suleiman, M. S., George, S. J., Loubani, M., & Morice, A. (2017). Hypoxic pulmonary vasoconstriction in humans: Tale or myth. Open Cardiovascular Medicine Journal, 11, 1-13.

Journal Article Type Review
Acceptance Date Dec 9, 2016
Online Publication Date Jan 24, 2017
Publication Date 2017
Deposit Date May 10, 2022
Publicly Available Date May 23, 2022
Journal Open Cardiovascular Medicine Journal
Electronic ISSN 1874-1924
Publisher Bentham Open
Peer Reviewed Peer Reviewed
Volume 11
Pages 1-13
Keywords Hypoxic Pulmonary Vasoconstriction; Human; Acute hypoxia; Chronic hypoxia; Pulmonary hypertension
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Copyright Statement
© Hussain et al.; Licensee Bentham Open

Open-Access License: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

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