Skip to main content

Research Repository

Advanced Search

Double-blind, placebo-controlled trial of mifepristone on cognition and depression in alcohol dependence

Donoghue, Kim; Rose, Abigail; Coulton, Simon; Coleman, Rachel; Milward, Joanna; Philips, Thomas; Drummond, Colin; Little, Hilary

Authors

Kim Donoghue

Abigail Rose

Simon Coulton

Rachel Coleman

Joanna Milward

Colin Drummond

Hilary Little



Abstract

Alcohol dependence is a significant issue contributing to disease burden. Changes in cortisol concentrations during alcohol withdrawal are associated with cognitive deficits and symptoms of depression. Current treatments are only successful for a small proportion of people and do not target cognitive deficits and symptoms of depression experienced by those who are alcohol dependent. The aim of this research is to determine the potential efficacy of mifepristone, a type II glucocorticoid receptor antagonist, to prevent symptoms of depression and cognitive deficits following alcohol detoxification.

Citation

Donoghue, K., Rose, A., Coulton, S., Coleman, R., Milward, J., Philips, T., …Little, H. (2020). Double-blind, placebo-controlled trial of mifepristone on cognition and depression in alcohol dependence. Trials, 21(1), https://doi.org/10.1186/s13063-020-04726-z

Journal Article Type Article
Acceptance Date Sep 5, 2020
Online Publication Date Sep 16, 2020
Publication Date 2020
Deposit Date Nov 9, 2020
Publicly Available Date Nov 10, 2020
Journal Trials
Print ISSN 1745-6215
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 21
Issue 1
Article Number 796
DOI https://doi.org/10.1186/s13063-020-04726-z
Keywords Alcohol dependence; Memory; Cognitive function; Depression; Cortisol; Glucocorticoid type II receptor; Mifepristone
Public URL https://hull-repository.worktribe.com/output/3606430
Publisher URL https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04726-z

Files

Published article (784 Kb)
PDF

Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/

Copyright Statement
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.



You might also like



Downloadable Citations