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Double-blind, placebo-controlled trial of mifepristone on cognition and depression in alcohol dependence

Donoghue, Kim; Rose, Abigail; Coulton, Simon; Coleman, Rachel; Milward, Joanna; Philips, Thomas; Drummond, Colin; Little, Hilary


Kim Donoghue

Abigail Rose

Simon Coulton

Rachel Coleman

Joanna Milward

Colin Drummond

Hilary Little


Alcohol dependence is a significant issue contributing to disease burden. Changes in cortisol concentrations during alcohol withdrawal are associated with cognitive deficits and symptoms of depression. Current treatments are only successful for a small proportion of people and do not target cognitive deficits and symptoms of depression experienced by those who are alcohol dependent. The aim of this research is to determine the potential efficacy of mifepristone, a type II glucocorticoid receptor antagonist, to prevent symptoms of depression and cognitive deficits following alcohol detoxification.


Donoghue, K., Rose, A., Coulton, S., Coleman, R., Milward, J., Philips, T., …Little, H. (2020). Double-blind, placebo-controlled trial of mifepristone on cognition and depression in alcohol dependence. Trials, 21(1),

Journal Article Type Article
Acceptance Date Sep 5, 2020
Online Publication Date Sep 16, 2020
Publication Date 2020
Deposit Date Nov 9, 2020
Publicly Available Date Nov 10, 2020
Journal Trials
Print ISSN 1745-6215
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 21
Issue 1
Article Number 796
Keywords Alcohol dependence; Memory; Cognitive function; Depression; Cortisol; Glucocorticoid type II receptor; Mifepristone
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