Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia

Moin, Abu Saleh Md; Al-Qaissi, Ahmed; Sathyapalan, Thozhukat; Atkin, Stephen L.; Butler, Alexandra E.

Abstract

Objective
Hypoglycemia in diabetes (T2D) may increase the risk for Alzheimer's disease (AD). We hypothesized that hypoglycemia‐induced amyloid‐related protein changes would be exacerbated in T2D.

Methods
A prospective, parallel study in T2D (n=23) and controls (n=23). Subjects underwent insulin‐induced hypoglycemia with blood sampling at baseline, hypoglycemia and post‐hypoglycemia; proteomic analysis of amyloid‐related proteins was undertaken.

Results
At baseline: Amyloid‐precursor protein (APP) (p

Citation

Moin, A. S. M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (in press). Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia. Diabetes, Obesity and Metabolism, https://doi.org/10.1111/dom.14220

• Journal Article Type: Article
• Acceptance Date: Oct 4, 2020
• Online Publication Date: Oct 7, 2020
• Deposit Date: Oct 13, 2020
• Publicly Available Date: Oct 8, 2021
• Journal: Diabetes, Obesity and Metabolism
• Print ISSN: 1462-8902
• Electronic ISSN: 1463-1326
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1111/dom.14220
• Keywords: Type 2 diabetes; Hypoglycemia; Dementia; Alzheimer's disease; Amyloid‐related proteins
• Public URL: https://hull-repository.worktribe.com/output/3633660
• Publisher URL: https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14220