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Cytotoxic effects of Ridolfia segetum (L.) Moris phytoproducts in cancer cells

Beeby, Ellie; Magalhães, Mariana; Lemos, Marco F L; Pires, Isabel M.; Cabral, Célia


Ellie Beeby

Mariana Magalhães

Marco F L Lemos

Célia Cabral


Ethnopharmacological relevance: The past few years have witnessed an increasing interest in essential oils (EOs) as potential therapeutic agents against a wide variety of pathologies, including cancer. EOs extracted from Ridolfia segetum (L.) Moris (R. segetum) are a clear example of a phytoproduct with therapeutic applications, as it is widely used in traditional medicine due to its antioxidant and anti-inflammatory properties, and these properties were already validated by previous studies. Although, it is well established that inflammation is a key hallmark of cancer, with a key role promoting tumorigenesis, and being chronic inflammation often associated with tumorigenic processes, there are no previous studies regarding the assessment of the antitumoural potential of R. segetum EOs. Aim of the study: The present study intends to be the first to evaluate the antitumoural proprieties of R. segetum EO phytoproducts in cancer cell models. Materials and methods: For this, R. segetum EOs were extracted from plants collected at either flowering (RS_Fl) or fruiting (RS_Fr) stage. The impact on proliferation and viability of treatment with R. segetum EO extracts was assessed using in vitro 2D and 3D models. Results: Both R. segetum EOs presented effective antiproliferative/viability effects, evidence noted by low IC50 values in 2D models, and significant reduction of spheroid size in 3D in vitro models. Mechanistically, treatment with R. segetum EOs was associated with an altered G1 (associated with p21 stabilisation), and subsequent induction of apoptosis. Conclusions: Overall, these results indicate that R. segetum EOs have potential as suitable antitumoural therapeutic agents.


Beeby, E., Magalhães, M., Lemos, M. F. L., Pires, I. M., & Cabral, C. (in press). Cytotoxic effects of Ridolfia segetum (L.) Moris phytoproducts in cancer cells. Journal of Ethnopharmacology, Article 113515.

Journal Article Type Article
Acceptance Date Oct 21, 2020
Online Publication Date Oct 24, 2020
Deposit Date Oct 23, 2020
Publicly Available Date Oct 25, 2021
Journal Journal of Ethnopharmacology
Print ISSN 0378-8741
Electronic ISSN 1872-7573
Publisher Elsevier
Peer Reviewed Peer Reviewed
Article Number 113515
Keywords Antitumour activity; Essential oil; Natural products; Ridolfia segetum
Public URL
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