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Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure

Samuel, Nathan A.; Cuthbert, Joseph J.; Brown, Oliver I.; Kazmi, Syed; Cleland, John G.F.; Rigby, Alan S.; Clark, Andrew L.


Nathan A. Samuel

Oliver I. Brown

Syed Kazmi

John G.F. Cleland

Andrew L. Clark


Thyroid dysfunction is common in patients with chronic heart failure (CHF), but there is conflicting evidence regarding its prognostic significance. We investigated the relation between thyroid function and prognosis in a large, well characterized cohort of ambulatory patients with CHF. Heart failure was defined as signs and symptoms of the disease and either left ventricular systolic dysfunction (LVSD) mild or worse (heart failure with reduced ejection fraction [HFrEF]), or no LVSD and raised amino-terminal pro-B-type natriuretic peptide (NT-proBNP) levels (>125 ng/L; heart failure with normal ejection fraction [HFnEF]). Euthyroid state was defined as a thyroid-stimulating hormone (TSH) level between 0.35 and 4.70 mIU/l, hypothyroidism as TSH >4.70 mIU/l, and hyperthyroidism as TSH


Samuel, N. A., Cuthbert, J. J., Brown, O. I., Kazmi, S., Cleland, J. G., Rigby, A. S., & Clark, A. L. (2021). Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure. The American journal of cardiology, 139, 57-63.

Journal Article Type Article
Acceptance Date Nov 2, 2020
Online Publication Date Oct 24, 2020
Publication Date Jan 15, 2021
Deposit Date Nov 26, 2020
Journal American Journal of Cardiology
Print ISSN 0002-9149
Electronic ISSN 1879-1913
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 139
Pages 57-63
Keywords Cardiology and Cardiovascular Medicine
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