Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure

Samuel, Nathan A.; Cuthbert, Joseph J.; Brown, Oliver I.; Kazmi, Syed; Cleland, John G.F.; Rigby, Alan S.; Clark, Andrew L.

doi:10.1016/j.amjcard.2020.10.034

Authors

Nathan A. Samuel

Mr Joe Cuthbert J.Cuthbert@hull.ac.uk
Academic Clinical Lecturer

Oliver I. Brown

Syed Kazmi

John G.F. Cleland

Professor Alan Rigby A.Rigby@hull.ac.uk
Professor of Statistics

Andrew L. Clark

Abstract

Thyroid dysfunction is common in patients with chronic heart failure (CHF), but there is conflicting evidence regarding its prognostic significance. We investigated the relation between thyroid function and prognosis in a large, well characterized cohort of ambulatory patients with CHF. Heart failure was defined as signs and symptoms of the disease and either left ventricular systolic dysfunction (LVSD) mild or worse (heart failure with reduced ejection fraction [HFrEF]), or no LVSD and raised amino-terminal pro-B-type natriuretic peptide (NT-proBNP) levels (>125 ng/L; heart failure with normal ejection fraction [HFnEF]). Euthyroid state was defined as a thyroid-stimulating hormone (TSH) level between 0.35 and 4.70 mIU/l, hypothyroidism as TSH >4.70 mIU/l, and hyperthyroidism as TSH

Citation

Samuel, N. A., Cuthbert, J. J., Brown, O. I., Kazmi, S., Cleland, J. G., Rigby, A. S., & Clark, A. L. (2021). Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure. The American journal of cardiology, 139, 57-63. https://doi.org/10.1016/j.amjcard.2020.10.034

Journal Article Type	Article
Acceptance Date	Nov 2, 2020
Online Publication Date	Oct 24, 2020
Publication Date	Jan 15, 2021
Deposit Date	Nov 26, 2020
Journal	American Journal of Cardiology
Print ISSN	0002-9149
Electronic ISSN	1879-1913
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	139
Pages	57-63
DOI	https://doi.org/10.1016/j.amjcard.2020.10.034
Keywords	Cardiology and Cardiovascular Medicine
Public URL	https://hull-repository.worktribe.com/output/3666984
Publisher URL	https://www.ajconline.org/article/S0002-9149(20)31140-1/fulltext
Related Public URLs	Accepted manuscript: http://eprints.gla.ac.uk/226180/ https://www.sciencedirect.com/science/article/abs/pii/S0002914920311401