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Reinforcement of calcium phosphate cement with multi-walled carbon nanotubes and bovine serum albumin for injectable bone substitute applications

Zein, S H; Chew, Kean-Khoon; Low, Kah-Ling; Chew, K K; Sharif Zein, Sharif Hussein; Gerhardt, L C; McPhail, David S.; Low, K L; Gerhardt, Lutz-Christian; Roether, Judith A.; Boccaccini, Aldo R.

Authors

Dr Sharif Zein S.H.Zein@hull.ac.uk
Director of Postgraduate Research, Chemical Engineering Department

Kean-Khoon Chew

Kah-Ling Low

K K Chew

Dr Sharif Zein S.H.Zein@hull.ac.uk
Director of Postgraduate Research, Chemical Engineering Department

L C Gerhardt

David S. McPhail

K L Low

Lutz-Christian Gerhardt

Judith A. Roether

Aldo R. Boccaccini



Abstract

This paper presents the development of novel alternative injectable calcium phosphate cement (CPC) composites for orthopaedic applications. The new CPC composites comprise β-tri-calcium phosphate (β-TCP) and di-calcium phosphate anhydrous (DCPA) mixed with bovine serum albumin (BSA) and incorporated with multi-walled carbon nanotubes (MWCNTs) or functionalized MWCNTs (MWCNTs-OH and MWCNTs-COOH). Scanning electron microscopy (SEM), compressive strength tests, injectability tests, Fourier transform infrared spectroscopy and X-ray diffraction were used to evaluate the properties of the final products. Compressive strength tests and SEM observations demonstrated particularly that the concomitant admixture of BSA and MWCNT improved the mechanical properties, resulting in stronger CPC composites. The presence of MWCNTs and BSA influenced the morphology of the hydroxyapatite (HA) crystals in the CPC matrix. BSA was found to act as a promoter of HA growth when bounded to the surface of CPC grains. MWCNT-OH-containing composites exhibited the highest compressive strengths (16.3 MPa), being in the range of values for trabecular bone (2-12 MPa). © 2010 Elsevier Ltd.

Journal Article Type Article
Publication Date 2011-04
Journal Journal Of The Mechanical Behavior Of Biomedical Materials
Print ISSN 1751-6161
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 4
Issue 3
Pages 331-339
Institution Citation Chew, K., Low, K., Sharif Zein, S. H., McPhail, D. S., Gerhardt, L., Roether, J. A., & Boccaccini, A. R. (2011). Reinforcement of calcium phosphate cement with multi-walled carbon nanotubes and bovine serum albumin for injectable bone substitute applications. Journal of the mechanical behavior of biomedical materials, 4(3), (331-339). doi:10.1016/j.jmbbm.2010.10.013. ISSN 1751-6161
DOI https://doi.org/10.1016/j.jmbbm.2010.10.013
Keywords Calcium phosphate cement (CPC); Carbon nanotubes (CNTs); Bovine serum albumin (BSA); Compressive strength; Injectability
Publisher URL https://www.sciencedirect.com/science/article/pii/S175161611000161X?via%3Dihub