Dr Sharif Zein S.H.Zein@hull.ac.uk
Senior Fellow HEA| Reader in Biorefinery Processes and Reaction Engineering| PI of Bioref Group
Reinforcement of calcium phosphate cement with multi-walled carbon nanotubes and bovine serum albumin for injectable bone substitute applications
Zein, S H; Chew, Kean-Khoon; Low, Kah-Ling; Chew, K K; Sharif Zein, Sharif Hussein; Gerhardt, L C; McPhail, David S.; Low, K L; Gerhardt, Lutz-Christian; Roether, Judith A.; Boccaccini, Aldo R.
Authors
Kean-Khoon Chew
Kah-Ling Low
K K Chew
Dr Sharif Zein S.H.Zein@hull.ac.uk
Senior Fellow HEA| Reader in Biorefinery Processes and Reaction Engineering| PI of Bioref Group
L C Gerhardt
David S. McPhail
K L Low
Lutz-Christian Gerhardt
Judith A. Roether
Aldo R. Boccaccini
Abstract
This paper presents the development of novel alternative injectable calcium phosphate cement (CPC) composites for orthopaedic applications. The new CPC composites comprise β-tri-calcium phosphate (β-TCP) and di-calcium phosphate anhydrous (DCPA) mixed with bovine serum albumin (BSA) and incorporated with multi-walled carbon nanotubes (MWCNTs) or functionalized MWCNTs (MWCNTs-OH and MWCNTs-COOH). Scanning electron microscopy (SEM), compressive strength tests, injectability tests, Fourier transform infrared spectroscopy and X-ray diffraction were used to evaluate the properties of the final products. Compressive strength tests and SEM observations demonstrated particularly that the concomitant admixture of BSA and MWCNT improved the mechanical properties, resulting in stronger CPC composites. The presence of MWCNTs and BSA influenced the morphology of the hydroxyapatite (HA) crystals in the CPC matrix. BSA was found to act as a promoter of HA growth when bounded to the surface of CPC grains. MWCNT-OH-containing composites exhibited the highest compressive strengths (16.3 MPa), being in the range of values for trabecular bone (2-12 MPa). © 2010 Elsevier Ltd.
Citation
Chew, K.-K., Low, K.-L., Sharif Zein, S. H., McPhail, D. S., Gerhardt, L.-C., Roether, J. A., & Boccaccini, A. R. (2011). Reinforcement of calcium phosphate cement with multi-walled carbon nanotubes and bovine serum albumin for injectable bone substitute applications. Journal of the mechanical behavior of biomedical materials, 4(3), 331-339. https://doi.org/10.1016/j.jmbbm.2010.10.013
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 31, 2010 |
Online Publication Date | Nov 12, 2010 |
Publication Date | 2011-04 |
Deposit Date | Nov 13, 2014 |
Journal | Journal Of The Mechanical Behavior Of Biomedical Materials |
Print ISSN | 1751-6161 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 4 |
Issue | 3 |
Pages | 331-339 |
DOI | https://doi.org/10.1016/j.jmbbm.2010.10.013 |
Keywords | Calcium phosphate cement (CPC); Carbon nanotubes (CNTs); Bovine serum albumin (BSA); Compressive strength; Injectability |
Public URL | https://hull-repository.worktribe.com/output/368795 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S175161611000161X?via%3Dihub |
Contract Date | Nov 13, 2014 |
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