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Mapping routine measles vaccination in low- and middle-income countries

Local Burden of Disease Vaccine Coverage Collaborators; Soyiri, Ireneous


Local Burden of Disease Vaccine Coverage Collaborators


The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs). Globally comparable, annual, local estimates of routine first-dose measles-containing vaccine (MCV1) coverage are critical for understanding geographically precise immunity patterns, progress towards the targets of the Global Vaccine Action Plan (GVAP), and high-risk areas amid disruptions to vaccination programmes caused by coronavirus disease 2019 (COVID-19). Here we generated annual estimates of routine childhood MCV1 coverage at 5 × 5-km2 pixel and second administrative levels from 2000 to 2019 in 101 LMICs, quantified geographical inequality and assessed vaccination status by geographical remoteness. After widespread MCV1 gains from 2000 to 2010, coverage regressed in more than half of the districts between 2010 and 2019, leaving many LMICs far from the GVAP goal of 80% coverage in all districts by 2019. MCV1 coverage was lower in rural than in urban locations, although a larger proportion of unvaccinated children overall lived in urban locations; strategies to provide essential vaccination services should address both geographical contexts. These results provide a tool for decision-makers to strengthen routine MCV1 immunization programmes and provide equitable disease protection for all children.


Local Burden of Disease Vaccine Coverage Collaborators, & Soyiri, I. (2021). Mapping routine measles vaccination in low- and middle-income countries. Nature, 589, 415-419.

Journal Article Type Article
Acceptance Date Nov 2, 2020
Online Publication Date Dec 16, 2020
Publication Date Jan 21, 2021
Deposit Date Jan 21, 2021
Publicly Available Date Jan 22, 2021
Journal Nature
Print ISSN 0028-0836
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 589
Pages 415-419
Keywords Disease prevention; Infectious diseases; Public health
Public URL
Publisher URL


Published article (59.1 Mb)

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