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The long-term prognostic significance of 6-minute walk test distance in patients with chronic heart failure

Ingle, Lee; Cleland, John G.; Clark, Andrew L.


John G. Cleland

Andrew L. Clark


Background. The 6-minute walk test (6-MWT) is used to assess patients with chronic heart failure (CHF). The prognostic significance of the 6-MWT distance during long-term followup ( > 5 years) is unclear. Methods. 1,667 patients (median [inter-quartile range, IQR]) (age 72 [65-77] ; 75% males) with heart failure due to left ventricular systolic impairment undertook a 6-MWT as part of their baseline assessment and were followed up for 5 years. Results. At 5 years' followup, those patients who died (n = 959) were older at baseline and had a higher log NT pro-BNP than those who survived to 5 years (n = 708). 6-MWT distance was lower in those who died [163 (153) m versus 269 (160) m; P < 0.0001]. Median 6-MWT distance was 300 (150-376) m, and quartile ranges were < 46 m, 46-240 m, 241-360 m, and > 360 m. 6-MWT distance was a predictor of all-cause mortality (HR 0.97; 95% CI 0.96-0.97; Chi-square = 184.1; P < 0.0001). Independent predictors of all-cause mortality were decreasing 6-MWT distance, increasing age, increasing NYHA classification, increasing log NT pro-BNP, decreasing diastolic blood pressure, decreasing sodium, and increasing urea. Conclusion. The 6-MWT is an important independent predictor of all-cause mortality following long-term followup in patients with CHF. © 2014 Lee Ingle et al.


Ingle, L., Cleland, J. G., & Clark, A. L. (2014). The long-term prognostic significance of 6-minute walk test distance in patients with chronic heart failure. Biomed research international, 2014, 1-7.

Journal Article Type Article
Acceptance Date Feb 26, 2014
Publication Date Mar 27, 2014
Deposit Date May 13, 2015
Publicly Available Date May 13, 2015
Journal BioMed research international
Print ISSN 2314-6133
Electronic ISSN 2314-6141
Publisher Hindawi
Peer Reviewed Peer Reviewed
Volume 2014
Article Number ARTN 505969
Pages 1-7
Keywords Heart failure; 6-minute walk test
Public URL
Publisher URL
Additional Information This is a copy of an article published in BioMed research international, 2014 which can also be found at:


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Copyright Statement
© 2014 Lee Ingle et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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