The long-term prognostic significance of 6-minute walk test distance in patients with chronic heart failure

Ingle, Lee; Cleland, John G.; Clark, Andrew L.

Abstract

Background. The 6-minute walk test (6-MWT) is used to assess patients with chronic heart failure (CHF). The prognostic significance of the 6-MWT distance during long-term followup ( > 5 years) is unclear. Methods. 1,667 patients (median [inter-quartile range, IQR]) (age 72 [65-77] ; 75% males) with heart failure due to left ventricular systolic impairment undertook a 6-MWT as part of their baseline assessment and were followed up for 5 years. Results. At 5 years' followup, those patients who died (n = 959) were older at baseline and had a higher log NT pro-BNP than those who survived to 5 years (n = 708). 6-MWT distance was lower in those who died [163 (153) m versus 269 (160) m; P < 0.0001]. Median 6-MWT distance was 300 (150-376) m, and quartile ranges were < 46 m, 46-240 m, 241-360 m, and > 360 m. 6-MWT distance was a predictor of all-cause mortality (HR 0.97; 95% CI 0.96-0.97; Chi-square = 184.1; P < 0.0001). Independent predictors of all-cause mortality were decreasing 6-MWT distance, increasing age, increasing NYHA classification, increasing log NT pro-BNP, decreasing diastolic blood pressure, decreasing sodium, and increasing urea. Conclusion. The 6-MWT is an important independent predictor of all-cause mortality following long-term followup in patients with CHF. © 2014 Lee Ingle et al.

Citation

Ingle, L., Cleland, J. G., & Clark, A. L. (2014). The long-term prognostic significance of 6-minute walk test distance in patients with chronic heart failure. Biomed research international, 2014, 1-7. https://doi.org/10.1155/2014/505969

• Journal Article Type: Article
• Acceptance Date: Feb 26, 2014
• Publication Date: Mar 27, 2014
• Deposit Date: May 13, 2015
• Publicly Available Date: May 13, 2015
• Journal: BioMed research international
• Print ISSN: 2314-6133
• Publisher: Hindawi
• Peer Reviewed: Peer Reviewed
• Volume: 2014
• Article Number: ARTN 505969
• Pages: 1-7
• DOI: https://doi.org/10.1155/2014/505969
• Keywords: Heart failure; 6-minute walk test
• Public URL: https://hull-repository.worktribe.com/output/373735
• Publisher URL: http://www.hindawi.com/journals/bmri/2014/505969/
• Additional Information: This is a copy of an article published in BioMed research international, 2014 which can also be found at: http://www.hindawi.com/journals/bmri/2014/505969/
• Contract Date: May 13, 2015