Stéphanie C. Choisy
Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats
Choisy, Stéphanie C.; Kim, Shang-Jin; Hancox, Jules C.; Jones, Sandra A.; James, Andrew F.
Jules C. Hancox
Dr Sandra Jones S.A.Jones@hull.ac.uk
Senior Lecturer in Biomedical Science
Andrew F. James
Hypertension-induced structural remodeling of the left atrium (LA) has been suggested to involve the renin–angiotensin system. This study investigated whether treatment with an angiotensin receptor blocker, candesartan, regresses atrial remodeling in spontaneously hypertensive rats (SHR). Effects of treatment with candesartan were compared to treatment with a nonspecific vasodilatator, hydralazine. Thirty to 32-week-old adult male SHR were either untreated (n = 15) or received one of either candesartan cilexetil (n = 9; 3 mg/kg/day) or hydralazine (n = 10; 14 mg/kg/day) via their drinking water for 14 weeks prior to experiments. Untreated age- and sex-matched Wistar- Kyoto rats (WKY; n = 13) represented a normotensive control group. Untreated SHR were hypertensive, with left ventricular hypertrophy (LVH) compared to WKY, but there were no differences in systolic pressures in excised, perfused hearts. LA from SHR were hypertrophied and showed increased fibrosis compared to those from WKY, but there was no change in connexin-43 expression or phosphorylation. Treatment with candesartan reduced systolic tail artery pressures of conscious SHR below those of normotensive WKY and caused regression of both LVH and LA hypertrophy. Although hydralazine reduced SHR arterial pressures to those of WKY and led to regression of LA hypertrophy, it had no significant effect on LVH. Notably, LA fibrosis was unaffected by treatment with either agent. These data show that candesartan, at a dose sufficient to reduce blood pressure and LVH, did not cause regression of LA fibrosis in hypertensive rats. On the other hand, the data also suggest that normalization of arterial pressure can lead to the regression of LA hypertrophy.
Choisy, S. C., Kim, S., Hancox, J. C., Jones, S. A., & James, A. F. (2015). Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats. Physiological Reports, 3(1), e12274. https://doi.org/10.14814/phy2.12274
|Journal Article Type||Article|
|Acceptance Date||Dec 19, 2014|
|Online Publication Date||Jan 27, 2015|
|Deposit Date||May 26, 2015|
|Publicly Available Date||May 26, 2015|
|Peer Reviewed||Peer Reviewed|
|Keywords||Angiotensin receptor blocker; Connexin-43; Fibrosis; Gap junction|
|Additional Information||Copy of article: S. C. Choisy, S. J. Kim, J. C. Hancox, S. A. Jones, A. F. James, Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats, Physiol Rep, 3 (1), 2015, e12274, doi: 10.14814/phy2.12274|
© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.<br /> <br /> This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.