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Detection of mecC-Methicillin-resistant Staphylococcus aureus isolates in river water : a potential role for water in the environmental dissemination

Domínguez, Lucas; Harrison, Ewan; Concepcion Porrero, M.; Francisco Fernandez-Garayzabal, Jose; Diez-Guerrier, Alberto; Dominguez, Lucas; Porrero, M. Concepción; Harrison, Ewan M; Fernández-Garayzábal, José Francisco; Paterson, Gavin K.; Díez-Guerrier, Alberto; Holmes, Mark A.; Domínguez Rodríguez, Lucas

Authors

Lucas Domínguez

Ewan Harrison

M. Concepcion Porrero

Jose Francisco Fernandez-Garayzabal

Alberto Diez-Guerrier

Lucas Dominguez

M. Concepción Porrero

Ewan M Harrison

José Francisco Fernández-Garayzábal

Gavin K. Paterson

Alberto Díez-Guerrier

Mark A. Holmes

Lucas Domínguez Rodríguez

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a public health concern due to limited treatment options. The recent description of a mecA homologue, mecC in human and cattle, led to studies to detect this new variant in human and other animal species. Detection of mecC in wild boar and fallow deer in a Spanish game estate led us to further investigate the presence of mecC-MRSA at this location. Samples from cattle, wild animals, workers and river water were tested. A further three mecC-MRSA isolates were obtained from river water. Molecular characterization (multilocus sequence typing and spa typing) and antimicrobial susceptibility testing (broth microdilution) showed that isolates were similar to those detected in wild animals. Whole genome sequencing confirmed that the isolates from the river water and wild animals in the same geographic area were all closely related isolates of ST425 mecC-MRSA. The presence of mecC-MRSA in the river water highlights the potential role of water in the dissemination of mecC-MRSA.

Journal Article Type Article
Publication Date 2014-11
Journal Environmental microbiology reports
Print ISSN 1758-2229
Electronic ISSN 1758-2229
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 6
Issue 6
Pages 705-708
Institution Citation Porrero, M. C., Harrison, E. M., Fernández-Garayzábal, J. F., Paterson, G. K., Díez-Guerrier, A., Holmes, M. A., & Domínguez Rodríguez, L. (2014). Detection of mecC-Methicillin-resistant Staphylococcus aureus isolates in river water : a potential role for water in the environmental dissemination. Environmental microbiology reports, 6(6), 705-708. https://doi.org/10.1111/1758-2229.12191
DOI https://doi.org/10.1111/1758-2229.12191
Keywords mecC, MRSA, Waterborne infection
Publisher URL http://onlinelibrary.wiley.com/doi/10.1111/1758-2229.12191/abstract
Copyright Statement ©2015 University of Hull
Additional Information Author's accepted manuscript of article published in: Environmental microbiology reports, 2014, v.6, issue 6

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