Detection of mecC-Methicillin-resistant Staphylococcus aureus isolates in river water : a potential role for water in the environmental dissemination

Porrero, M. Concepción; Harrison, Ewan M; Fernández-Garayzábal, José Francisco; Paterson, Gavin K.; Díez-Guerrier, Alberto; Holmes, Mark A.; Domínguez Rodríguez, Lucas

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a public health concern due to limited treatment options. The recent description of a mecA homologue, mecC in human and cattle, led to studies to detect this new variant in human and other animal species. Detection of mecC in wild boar and fallow deer in a Spanish game estate led us to further investigate the presence of mecC-MRSA at this location. Samples from cattle, wild animals, workers and river water were tested. A further three mecC-MRSA isolates were obtained from river water. Molecular characterization (multilocus sequence typing and spa typing) and antimicrobial susceptibility testing (broth microdilution) showed that isolates were similar to those detected in wild animals. Whole genome sequencing confirmed that the isolates from the river water and wild animals in the same geographic area were all closely related isolates of ST425 mecC-MRSA. The presence of mecC-MRSA in the river water highlights the potential role of water in the dissemination of mecC-MRSA.

Citation

Porrero, M. C., Harrison, E. M., Fernández-Garayzábal, J. F., Paterson, G. K., Díez-Guerrier, A., Holmes, M. A., & Domínguez Rodríguez, L. (2014). Detection of mecC-Methicillin-resistant Staphylococcus aureus isolates in river water : a potential role for water in the environmental dissemination. Environmental microbiology reports, 6(6), 705-708. https://doi.org/10.1111/1758-2229.12191

• Journal Article Type: Article
• Acceptance Date: Jun 11, 2014
• Online Publication Date: Jun 22, 2014
• Publication Date: 2014-11
• Deposit Date: Jun 29, 2015
• Publicly Available Date: Jun 29, 2015
• Journal: Environmental microbiology reports
• Print ISSN: 1758-2229
• Electronic ISSN: 1758-2229
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Issue: 6
• Pages: 705-708
• DOI: https://doi.org/10.1111/1758-2229.12191
• Keywords: mecC, MRSA, Waterborne infection
• Public URL: https://hull-repository.worktribe.com/output/375887
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1111/1758-2229.12191/abstract
• Additional Information: Author's accepted manuscript of article published in: Environmental microbiology reports, 2014, v.6, issue 6