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Pretreatment prognostic value of dynamic contrast-enhanced magnetic resonance imaging vascular, texture, shape, and size parameters compared with traditional survival indicators obtained from locally advanced breast cancer patients

Pickles, Martin D.; Lowry, Martin; Gibbs, Peter

Authors

Martin D. Pickles

Martin Lowry

Peter Gibbs

Abstract

Objectives: The aim of this study was to determine if associations exist between pretreatment dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI)-based metrics (vascular kinetics, texture, shape, size) and survival intervals. Furthermore, the aim of this study was to compare the prognostic value of DCE-MRI parameters against traditional pretreatment survival indicators. Materials and Methods: A retrospective study was undertaken. Approval had previously been granted for the retrospective use of such data, and the need for informed consent was waived. Prognostic value of pretreatment DCE-MRI parameters and clinical data was assessed via Cox proportional hazards models. The variables retained by the final overall survival Cox proportional hazards model were utilized to stratify risk of death within 5 years. Results: One hundred twelve subjects were entered into the analysis. Regarding disease-free survival-negative estrogen receptor status, T3 or higher clinical tumor stage, large ( > 9.8 cm 3 ) MR tumor volume, higher 95th percentile ( > 79%) percentage enhancement, and reduced ( > 0.22) circularity represented the retained model variables. Similar results were noted for the overall survival with negative estrogen receptor status, T3 or higher clinical tumor stage, and large ( > 9.8 cm 3 ) MR tumor volume, again all been retained by the model in addition to higher ( > 0.71) 25th percentile area under the enhancement curve. Accuracy of risk stratification based on either traditional (59%) or DCEMRI (65%) survival indicators performed to a similar level. However, combined traditional and MR risk stratification resulted in the highest accuracy (86%). Conclusions: Multivariate survival analysis has revealed thatmodel-retained DCEMRI variables provide independent prognostic information complementing traditional survival indicators and as such could help to appropriately stratify treatment.

Journal Article Type Article
Publication Date 2016-03
Journal Investigative radiology
Print ISSN 0020-9996
Electronic ISSN 1536-0210
Publisher Lippincott, Williams & Wilkins
Peer Reviewed Peer Reviewed
Volume 51
Issue 3
Pages 177-185
Institution Citation Pickles, M. D., Lowry, M., & Gibbs, P. (2016). Pretreatment prognostic value of dynamic contrast-enhanced magnetic resonance imaging vascular, texture, shape, and size parameters compared with traditional survival indicators obtained from locally advanced breast cancer patients. Investigative radiology, 51(3), 177-185. https://doi.org/10.1097/RLI.0000000000000222
DOI https://doi.org/10.1097/RLI.0000000000000222
Keywords Radiology Nuclear Medicine and imaging; General Medicine
Publisher URL http://journals.lww.com/investigativeradiology/Abstract/publishahead/Pretreatment_Prognostic_Value_of_Dynamic.99259.aspxhttp://journals.lww.com/investigativeradiology/Abstract/publishahead/Pretreatment_Prognostic_Value_of_Dynamic.99259.aspx
Additional Information This is a non-final version of an article published in final form in Investigative Radiology. 51(3):177-185, March 2016.

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