Lesion T2 relaxation times and volumes predict the response of malignant breast lesions to neoadjuvant chemotherapy

Tan, P. Clara; Pickles, Martin D.; Lowry, Martin; Manton, David J.; Turnbull, Lindsay W.

doi:10.1016/j.mri.2007.04.002

Lesion T2 relaxation times and volumes predict the response of malignant breast lesions to neoadjuvant chemotherapy

Tan, P. Clara; Pickles, Martin D.; Lowry, Martin; Manton, David J.; Turnbull, Lindsay W.

Authors

P. Clara Tan

Martin D. Pickles

Martin Lowry

David J. Manton

Lindsay W. Turnbull

Abstract

The aim of this study was to investigate the utility of the water T-2 values of malignant breast lesions in predicting response after the first and second cycles of neoadjuvant chemotherapy (NAC), both alone and in combination with lesion volumes. Thirty-five patients were scanned before the commencement of chemotherapy and again after the first, second and final treatment cycles. Two methods of obtaining lesion T2 were used: imaging, where a series of T-2-weighted images was acquired (T-R/T-E = 1000/30, 60, 90 and 120 ms), and spectroscopy, where the T2 value of unsuppressed water signal was determined with a multiecho sequence (T-R = 1.5 s; initial T-E=35 ms; 64 steps of 2.5 ms; 2 unsuppressed acquisitions per T-E). Lesion volumes were computed from contrast-enhanced 3D fat-suppressed images. The study found that, using the imaging method of obtaining T2, the ratio of the product of lesion T2 and volume after the second cycle of NAC to pretreatment value is a good predictor of ultimate lesion response, defined as a >= 65% reduction in tumor volume after the final treatment cycle, with positive and negative predictive values of 95.5% and 84.6%, respectively. (c) 2008 Elsevier Inc. All rights reserved.

Citation

Tan, P. C., Pickles, M. D., Lowry, M., Manton, D. J., & Turnbull, L. W. (2008). Lesion T2 relaxation times and volumes predict the response of malignant breast lesions to neoadjuvant chemotherapy. Magnetic Resonance Imaging, 26(1), 26-34. https://doi.org/10.1016/j.mri.2007.04.002

Journal Article Type	Article
Acceptance Date	Apr 21, 2007
Online Publication Date	Jun 15, 2007
Publication Date	2008-01
Journal	MAGNETIC RESONANCE IMAGING
Print ISSN	0730-725X
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	26
Issue	1
Pages	26-34
DOI	https://doi.org/10.1016/j.mri.2007.04.002
Keywords	Breast cancer; Chemotherapy; Magnetic resonance imaging; Magnetic resonance spectroscopy; Water T2
Public URL	https://hull-repository.worktribe.com/output/391548
Publisher URL	https://www.sciencedirect.com/science/article/pii/S0730725X07002627?via%3Dihub#!