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Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

Archibald, S.J.; Baghdadi, N.; Tripier, R.; Gibbs, P.; Pickles, M.; Al-Yassiry, M.M.; Clemente, G.S.; Nigam, S.; Clemente, Goncalo S.; Tripier, Raphael; Burke, B.P.; Burke, Benjamin P.; Baghdadi, Neazar; Kownacka, Alicja E.; Nigam, Shubhanchi; Clemente, Gonçalo S.; Al-Yassiry, Mustafa M.; Domarkas, Juozas; Lorch, Mark; Pickles, Martin; Gibbs, Peter; Cawthorne, Christopher; Tripier, Raphaël; Archibald, Stephen J.

Authors

S.J. Archibald

N. Baghdadi

R. Tripier

P. Gibbs

M. Pickles

M.M. Al-Yassiry

G.S. Clemente

S. Nigam

Goncalo S. Clemente

Raphael Tripier

B.P. Burke

Benjamin P. Burke

Neazar Baghdadi

Alicja E. Kownacka

Shubhanchi Nigam

Gonçalo S. Clemente

Mustafa M. Al-Yassiry

Juozas Domarkas

Professor Mark Lorch M.Lorch@hull.ac.uk
Professor of Public Engagement and Science Communication. Interim Head of Department for Chemistry, Biochemistry and Chemical Engineering

Martin Pickles

Peter Gibbs

Christopher Cawthorne

Raphaël Tripier



Abstract

The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describe a new class of silica coated iron–oxide nanorods (NRs) coated with polyethylene glycol (PEG) and/or a tetraazamacrocyclic chelator (DO3A). Studies of the coated NRs validate their composition and confirm their properties as in vivo T₂ MRI contrast agents. Radiolabelling studies with the positron emitting radioisotope gallium-68 (t1/2 = 68 min) demonstrate that, in the presence of the silica coating, the macrocyclic chelator was not required for preparation of highly stable radiometal-NR constructs. In vivo PET-CT and MR imaging studies show the expected high liver uptake of gallium-68 radiolabelled nanorods with no significant release of gallium-68 metal ions, validating our innovation to provide a novel simple method for labelling of iron oxide NRs with a radiometal in the absence of a chelating unit that can be used for high sensitivity liver imaging.

Publication Date Aug 13, 2015
Journal Nanoscale
Print ISSN 2040-3364
Electronic ISSN 2040-3372
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 7
Issue 36
Pages 14889-14896
APA6 Citation Burke, B. P., Baghdadi, N., Kownacka, A. E., Nigam, S., Clemente, G. S., Al-Yassiry, M. M., …Archibald, S. J. (2015). Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions. Nanoscale, 7(36), 14889-14896. https://doi.org/10.1039/c5nr02753e
DOI https://doi.org/10.1039/c5nr02753e
Keywords Nanorods, Polyethylene glycol , Tetraazamacrocyclic chelator , Gallium-68 , Iron oxide
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2015/NR/C5NR02753E#!divAbstract
Copyright Statement This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Additional Information Copy of article first published in: Nanoscale, 2015, v.7, issue 36.

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Copyright Statement
© The Royal Society of Chemistry 2015. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.





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