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Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

Archibald, S.J.; Baghdadi, N.; Tripier, R.; Gibbs, P.; Pickles, M.; Al-Yassiry, M.M.; Clemente, G.S.; Nigam, S.; Clemente, Goncalo S.; Tripier, Raphael; Burke, B.P.; Burke, Benjamin P.; Baghdadi, Neazar; Kownacka, Alicja E.; Nigam, Shubhanchi; Clemente, Gonçalo S.; Al-Yassiry, Mustafa M.; Domarkas, Juozas; Lorch, Mark; Pickles, Martin; Gibbs, Peter; Cawthorne, Christopher; Tripier, Raphaël; Archibald, Stephen J.

Authors

S.J. Archibald

N. Baghdadi

R. Tripier

P. Gibbs

M. Pickles

M.M. Al-Yassiry

G.S. Clemente

S. Nigam

Goncalo S. Clemente

Raphael Tripier

B.P. Burke

Benjamin P. Burke

Neazar Baghdadi

Alicja E. Kownacka

Shubhanchi Nigam

Gonçalo S. Clemente

Mustafa M. Al-Yassiry

Juozas Domarkas

Martin Pickles

Peter Gibbs

Christopher Cawthorne

Raphaël Tripier

Abstract

The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describe a new class of silica coated iron–oxide nanorods (NRs) coated with polyethylene glycol (PEG) and/or a tetraazamacrocyclic chelator (DO3A). Studies of the coated NRs validate their composition and confirm their properties as in vivo T₂ MRI contrast agents. Radiolabelling studies with the positron emitting radioisotope gallium-68 (t1/2 = 68 min) demonstrate that, in the presence of the silica coating, the macrocyclic chelator was not required for preparation of highly stable radiometal-NR constructs. In vivo PET-CT and MR imaging studies show the expected high liver uptake of gallium-68 radiolabelled nanorods with no significant release of gallium-68 metal ions, validating our innovation to provide a novel simple method for labelling of iron oxide NRs with a radiometal in the absence of a chelating unit that can be used for high sensitivity liver imaging.

Publication Date Aug 13, 2015
Journal Nanoscale
Print ISSN 2040-3364
Electronic ISSN 2040-3372
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 7
Issue 36
Pages 14889-14896
Institution Citation Burke, B. P., Baghdadi, N., Kownacka, A. E., Nigam, S., Clemente, G. S., Al-Yassiry, M. M., …Archibald, S. J. (2015). Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions. Nanoscale, 7(36), 14889-14896. https://doi.org/10.1039/c5nr02753e
DOI https://doi.org/10.1039/c5nr02753e
Keywords Nanorods, Polyethylene glycol , Tetraazamacrocyclic chelator , Gallium-68 , Iron oxide
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2015/NR/C5NR02753E#!divAbstract
Copyright Statement This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Additional Information Copy of article first published in: Nanoscale, 2015, v.7, issue 36.

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Copyright Statement
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.




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