Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic

Maruani, Antoine; Savoie, Huguette; Bryden, Francesca; Caddick, Stephen; Boyle, Ross; Chudasama, Vijay

Abstract

Herein we present a significant step towards next-generation antibody-based photodynamic therapeutics. Site-selective modification of a clinically relevant monoclonal antibody, with a serum-stable linker bearing a strained alkyne, allows for the controlled Cu-free “click” assembly of an in vitro active antibody-based PDT agent using a water soluble azide porpyhrin.

Citation

Maruani, A., Savoie, H., Bryden, F., Caddick, S., Boyle, R., & Chudasama, V. (2015). Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic. Chemical communications : Chem comm / the Royal Society of Chemistry, 51(83), 15304-15307. https://doi.org/10.1039/c5cc06985h

• Journal Article Type: Article
• Acceptance Date: Aug 24, 2015
• Online Publication Date: Aug 24, 2015
• Publication Date: Oct 25, 2015
• Deposit Date: Oct 30, 2015
• Publicly Available Date: Nov 23, 2017
• Journal: Chemical communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 51
• Issue: 83
• Pages: 15304-15307
• DOI: https://doi.org/10.1039/c5cc06985h
• Keywords: Multi-porphyrin attachment , Photodynamic therapeutics
• Public URL: https://hull-repository.worktribe.com/output/380603
• Publisher URL: http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC06985H#!divAbstract
• Additional Information: Authors' accepted manuscript of an article which has been published in: Chemical communications, 2015, v.51, issue 83.