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Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic

Maruani, Antoine; Savoie, Huguette; Bryden, Francesca; Caddick, Stephen; Boyle, Ross; Chudasama, Vijay

Authors

Antoine Maruani

Huguette Savoie

Francesca Bryden

Stephen Caddick

Vijay Chudasama



Abstract

Herein we present a significant step towards next-generation antibody-based photodynamic therapeutics. Site-selective modification of a clinically relevant monoclonal antibody, with a serum-stable linker bearing a strained alkyne, allows for the controlled Cu-free “click” assembly of an in vitro active antibody-based PDT agent using a water soluble azide porpyhrin.

Journal Article Type Article
Publication Date Oct 25, 2015
Journal Chemical communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 51
Issue 83
Pages 15304-15307
Institution Citation Maruani, A., Savoie, H., Bryden, F., Caddick, S., Boyle, R., & Chudasama, V. (2015). Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic. Chemical communications : Chem comm / the Royal Society of Chemistry, 51(83), 15304-15307. https://doi.org/10.1039/c5cc06985h
DOI https://doi.org/10.1039/c5cc06985h
Keywords Multi-porphyrin attachment , Photodynamic therapeutics
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC06985H#!divAbstract
Copyright Statement ©2016 University of Hull
Additional Information Authors' accepted manuscript of an article which has been published in: Chemical communications, 2015, v.51, issue 83.

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