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Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic

Maruani, Antoine; Savoie, Huguette; Bryden, Francesca; Caddick, Stephen; Boyle, Ross; Chudasama, Vijay

Authors

Antoine Maruani

Huguette Savoie

Francesca Bryden

Stephen Caddick

Ross Boyle

Vijay Chudasama



Abstract

Herein we present a significant step towards next-generation antibody-based photodynamic therapeutics. Site-selective modification of a clinically relevant monoclonal antibody, with a serum-stable linker bearing a strained alkyne, allows for the controlled Cu-free “click” assembly of an in vitro active antibody-based PDT agent using a water soluble azide porpyhrin.

Citation

Maruani, A., Savoie, H., Bryden, F., Caddick, S., Boyle, R., & Chudasama, V. (2015). Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic. Chemical communications : Chem comm / the Royal Society of Chemistry, 51(83), 15304-15307. https://doi.org/10.1039/c5cc06985h

Journal Article Type Article
Acceptance Date Aug 24, 2015
Online Publication Date Aug 24, 2015
Publication Date Oct 25, 2015
Deposit Date Oct 30, 2015
Publicly Available Date Nov 23, 2017
Journal Chemical communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 51
Issue 83
Pages 15304-15307
DOI https://doi.org/10.1039/c5cc06985h
Keywords Multi-porphyrin attachment , Photodynamic therapeutics
Public URL https://hull-repository.worktribe.com/output/380603
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC06985H#!divAbstract
Copyright Statement ©2016 University of Hull
Additional Information Authors' accepted manuscript of an article which has been published in: Chemical communications, 2015, v.51, issue 83.

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