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Huisgen-based conjugation of water-soluble porphyrins to deprotected sugars: Towards mild strategies for the labelling of glycans

Giuntini, Francesca; Bryden, Francesca; Daly, Robin; Scanlan, Eoin M.; Boyle, Ross W.

Authors

Francesca Giuntini

Francesca Bryden

Robin Daly

Eoin M. Scanlan

Professor Ross Boyle R.W.Boyle@hull.ac.uk
Professor of Biological Chemistry/ Module Coordinator for Biological Macromolecules/ Biological Safety and Genetic Modifications Committee Member

Abstract

Fully deprotected alkynyl-functionalised mono- and oligosaccharides undergo CuAAC-based conjugation with water-soluble porphyrin azides in aqueous environments. The mild reaction conditions are fully compatible with the presence of labile glycosidic bonds. This approach provides an ideal strategy to conjugate tetrapyrroles to complex carbohydrates.

Journal Article Type Article
Publication Date Feb 28, 2014
Journal Organic & biomolecular chemistry
Print ISSN 1477-0520
Electronic ISSN 1477-0539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 12
Issue 8
Pages 1203-1206
Institution Citation Giuntini, F., Bryden, F., Daly, R., Scanlan, E. M., & Boyle, R. W. (2014). Huisgen-based conjugation of water-soluble porphyrins to deprotected sugars: Towards mild strategies for the labelling of glycans. Organic & biomolecular chemistry, 12(8), 1203-1206. https://doi.org/10.1039/c3ob42306a
DOI https://doi.org/10.1039/c3ob42306a
Keywords Water-soluble porphyrins; Glycans; Deprotected sugars
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2014/OB/c3ob42306a#!divAbstract
Copyright Statement Creative Commons Attribution 3.0 Unported Licence.
Additional Information Copy of article first published in: Organic & biomolecular chemistry, 2014, v.12, issue 8.

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Copyright Statement
Creative Commons Attribution 3.0 Unported Licence.



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