F. Giuntini
Conjugatable water-soluble Pt(ii) and Pd(ii) porphyrin complexes: Novel nano- and molecular probes for optical oxygen tension measurement in tissue engineering
Giuntini, F.; Chauhan, V. M.; Aylott, J. W.; Rosser, G. A.; Athanasiadis, A.; Beeby, A.; MacRobert, A. J.; Brown, R. A.; Boyle, R. W.
Authors
V. M. Chauhan
J. W. Aylott
G. A. Rosser
A. Athanasiadis
A. Beeby
A. J. MacRobert
R. A. Brown
Professor Ross Boyle R.W.Boyle@hull.ac.uk
Professor of Biological Chemistry
Abstract
Measurement of oxygen tension in compressed collagen sheets was performed using matrix-embedded optical oxygen sensors based on platinum(II) and palladium(II) porphyrins supported on polyacrylamide nanoparticles. Bespoke, fully water-soluble, mono-functionalised Pt(II) and Pd(II) porphyrin complexes designed for conjugation under mild conditions were obtained using microwave-assisted metallation. The new sensors display a linear response (1/τ vs. O₂) to varying oxygen tension over a biologically relevant range (7.0 × 10⁻⁴ to 2.7 × 10⁻¹ mM) in aqueous solutions; a behaviour that is maintained following conjugation to polyacrylamide nanoparticles, and following embedding of the nanosensors in compressed collagen sheets, paving the way to innovative approaches for real-time resolution of oxygen gradients throughout 3D matrices useful for tissue regeneration.
Citation
Giuntini, F., Chauhan, V. M., Aylott, J. W., Rosser, G. A., Athanasiadis, A., Beeby, A., MacRobert, A. J., Brown, R. A., & Boyle, R. W. (2014). Conjugatable water-soluble Pt(ii) and Pd(ii) porphyrin complexes: Novel nano- and molecular probes for optical oxygen tension measurement in tissue engineering. Photochemical & photobiological sciences : an international journal, 13(7), 1039-1051. https://doi.org/10.1039/c4pp00026a
Acceptance Date | Apr 30, 2014 |
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Online Publication Date | Apr 30, 2014 |
Publication Date | Apr 30, 2014 |
Deposit Date | Aug 28, 2015 |
Publicly Available Date | Nov 23, 2017 |
Journal | Photochemical & photobiological sciences |
Print ISSN | 1474-905X |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 13 |
Issue | 7 |
Pages | 1039-1051 |
DOI | https://doi.org/10.1039/c4pp00026a |
Keywords | Oxygen tension, Porphyrin complexes , Tissue engineering |
Public URL | https://hull-repository.worktribe.com/output/378261 |
Publisher URL | http://pubs.rsc.org/en/Content/ArticleLanding/2014/PP/c4pp00026a#!divAbstract |
Additional Information | Copy of article first published in: Photochemical & photobiological sciences, 2014, v.13, issue 7. |
Contract Date | Nov 23, 2017 |
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Copyright Statement
©2015 University of Hull
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