Professor Thozhukat Sathyapalan T.Sathyapalan@hull.ac.uk
Professor of Diabetes, Endocrinology and Metabolism
Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis
Sathyapalan, T.; Atkin, S. L.; David, R.; Gooderham, N. J.
Authors
S. L. Atkin
R. David
N. J. Gooderham
Abstract
MicroRNAs (miRNA) are a novel class of small noncoding single-stranded RNA molecules that regulate gene expression. There is increasing evidence of their importance in polycystic ovary syndrome (PCOS). The objective was to determine if miRNA-93 and miRNA-223 are differentially expressed in the circulation of women with PCOS compared to age matched women. A case–control study comparing women with PCOS (n = 25) to age and weight matched controls (n = 24) without PCOS was performed. MiRNA-93 and miRNA-223 were determined by total RNA reverse transcription. Both miRNA-93 and miRNA-223 were significantly increased relative to the control group (p < 0.01, p = 0.029 respectively). In both groups there was no correlation of either miRNA-93 or miRNA-223 with insulin, HOMA-IR, HOMA-β or testosterone levels. The area under the receiver operator characteristic curve for miR-223 and miR-93 was 0.66 and 0.72 respectively, suggesting miR-93 is a more efficient biomarker than miR-223 for diagnosis of PCOS. The combination of the two miRNAs together, tested using multiple logistic regression analysis, did not improve the diagnostic potential. In conclusion, circulating miRNA-93 and miRNA-223 were higher in women with PCOS compared to age and weight matched controls independent of insulin resistance and testosterone levels, and miR-93 may represent a novel diagnostic biomarker for PCOS.
Citation
Sathyapalan, T., Atkin, S. L., David, R., & Gooderham, N. J. (2015). Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis. Scientific reports, 5(1), 16890-1-16890-8. https://doi.org/10.1038/srep16890
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 12, 2015 |
Online Publication Date | Nov 19, 2015 |
Publication Date | Nov 19, 2015 |
Deposit Date | Dec 18, 2015 |
Publicly Available Date | Mar 28, 2024 |
Journal | Scientific reports |
Print ISSN | 2045-2322 |
Electronic ISSN | 2045-2322 |
Publisher | Nature Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 5 |
Issue | 1 |
Article Number | ARTN 16890 |
Pages | 16890-1-16890-8 |
DOI | https://doi.org/10.1038/srep16890 |
Keywords | MicroRNAs (miRNA); Polycystic ovary syndrome (PCOS) |
Public URL | https://hull-repository.worktribe.com/output/383129 |
Publisher URL | http://www.nature.com/articles/srep16890 |
Additional Information | This is an open access article published in Scientific Reports, 2015, v.5. |
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