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Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis

Sathyapalan, T.; Atkin, S. L.; David, R.; Gooderham, N. J.


S. L. Atkin

R. David

N. J. Gooderham


MicroRNAs (miRNA) are a novel class of small noncoding single-stranded RNA molecules that regulate gene expression. There is increasing evidence of their importance in polycystic ovary syndrome (PCOS). The objective was to determine if miRNA-93 and miRNA-223 are differentially expressed in the circulation of women with PCOS compared to age matched women. A case–control study comparing women with PCOS (n = 25) to age and weight matched controls (n = 24) without PCOS was performed. MiRNA-93 and miRNA-223 were determined by total RNA reverse transcription. Both miRNA-93 and miRNA-223 were significantly increased relative to the control group (p < 0.01, p = 0.029 respectively). In both groups there was no correlation of either miRNA-93 or miRNA-223 with insulin, HOMA-IR, HOMA-β or testosterone levels. The area under the receiver operator characteristic curve for miR-223 and miR-93 was 0.66 and 0.72 respectively, suggesting miR-93 is a more efficient biomarker than miR-223 for diagnosis of PCOS. The combination of the two miRNAs together, tested using multiple logistic regression analysis, did not improve the diagnostic potential. In conclusion, circulating miRNA-93 and miRNA-223 were higher in women with PCOS compared to age and weight matched controls independent of insulin resistance and testosterone levels, and miR-93 may represent a novel diagnostic biomarker for PCOS.


Sathyapalan, T., Atkin, S. L., David, R., & Gooderham, N. J. (2015). Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis. Scientific reports, 5(1), 16890-1-16890-8.

Journal Article Type Article
Acceptance Date Oct 12, 2015
Online Publication Date Nov 19, 2015
Publication Date Nov 19, 2015
Deposit Date Dec 18, 2015
Publicly Available Date Oct 27, 2022
Journal Scientific reports
Print ISSN 2045-2322
Electronic ISSN 2045-2322
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 5
Issue 1
Article Number ARTN 16890
Pages 16890-1-16890-8
Keywords MicroRNAs (miRNA); Polycystic ovary syndrome (PCOS)
Public URL
Publisher URL
Additional Information This is an open access article published in Scientific Reports, 2015, v.5.


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