Gold nanoparticles: Multifaceted roles in the management of autoimmune disorders

Koushki, Khadijeh; Shahbaz, Sanaz Keshavarz; Keshavarz, Mohsen; Bezsonov, Evgeny E.; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

doi:10.3390/biom11091289

Gold nanoparticles: Multifaceted roles in the management of autoimmune disorders

Koushki, Khadijeh; Shahbaz, Sanaz Keshavarz; Keshavarz, Mohsen; Bezsonov, Evgeny E.; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Authors

Khadijeh Koushki

Sanaz Keshavarz Shahbaz

Mohsen Keshavarz

Evgeny E. Bezsonov

Professor Thozhukat Sathyapalan T.Sathyapalan@hull.ac.uk
Professor of Diabetes, Endocrinology and Metabolism

Amirhossein Sahebkar

Abstract

Gold nanoparticles (GNPs) have been recently applied for various diagnostic and therapeutic purposes. The unique properties of these nanoparticles (NPs), such as relative ease of synthesis in various sizes, shapes and charges, stability, high drug-loading capacity and relative availability for modification accompanied by non-cytotoxicity and biocompatibility, make them an ideal field of research in bio-nanotechnology. Moreover, their potential to alleviate various inflammatory factors, nitrite species, and reactive oxygen production and the capacity to deliver therapeutic agents has attracted attention for further studies in inflammatory and autoimmune disorders. Furthermore, the characteristics of GNPs and surface modification can modulate their toxicity, biodistribution, biocompatibility, and effects. This review discusses in vitro and in vivo effects of GNPs and their functionalized forms in managing various autoimmune disorders (Ads) such as rheumatoid arthritis, type 1 diabetes, and multiple sclerosis.

Citation

Koushki, K., Shahbaz, S. K., Keshavarz, M., Bezsonov, E. E., Sathyapalan, T., & Sahebkar, A. (2021). Gold nanoparticles: Multifaceted roles in the management of autoimmune disorders. Biomolecules, 11(9), Article 1289. https://doi.org/10.3390/biom11091289

Journal Article Type	Review
Acceptance Date	Aug 24, 2021
Online Publication Date	Aug 30, 2021
Publication Date	2021-09
Deposit Date	Oct 1, 2021
Publicly Available Date	Oct 4, 2021
Journal	Biomolecules
Electronic ISSN	2218-273X
Publisher	MDPI
Peer Reviewed	Peer Reviewed
Volume	11
Issue	9
Article Number	1289
DOI	https://doi.org/10.3390/biom11091289
Keywords	Gold nanoparticles; Autoimmune diseases; Immunomodulatory effects; Nanomedicine
Public URL	https://hull-repository.worktribe.com/output/3834724

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Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).