Outcomes and characteristics of COVID-19 patients treated with continuous positive airway pressure/high-flow nasal oxygen outside the intensive care setting

Sykes, Dominic L.; Crooks, Michael G.; Thu, Khaing Thu; Brown, Oliver I.; Tyrer, Theodore J.P.; Rennardson, Jodie; Littlefield, Catherine; Faruqi, Shoaib

Abstract

Background Continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) have been used to manage hypoxaemic respiratory failure secondary to coronavirus disease 2019 (COVID-19) pneumonia. Limited data are available for patients treated with noninvasive respiratory support outside of the intensive care setting. Methods In this single-centre observational study we observed the characteristics, physiological observations, laboratory tests and outcomes of all consecutive patients with COVID-19 pneumonia between April 2020 and March 2021 treated with noninvasive respiratory support outside of the intensive care setting. Results We report the outcomes of 140 patients (mean±SD age: 71.2±11.1, 65% male (n=91)) treated with CPAP/HFNO outside of the intensive care setting. Overall mortality was 59% and was higher in those deemed unsuitable for mechanical ventilation (72%). The mean age of survivors was significantly lower than those who died (66.1 versus 74.4 years, p

Citation

Sykes, D. L., Crooks, M. G., Thu, K. T., Brown, O. I., Tyrer, T. J., Rennardson, J., Littlefield, C., & Faruqi, S. (2021). Outcomes and characteristics of COVID-19 patients treated with continuous positive airway pressure/high-flow nasal oxygen outside the intensive care setting. ERJ Open Research, 7(4), Article 00318-2021. https://doi.org/10.1183/23120541.00318-2021

• Journal Article Type: Article
• Acceptance Date: Jul 5, 2021
• Online Publication Date: Jul 15, 2021
• Publication Date: Oct 1, 2021
• Deposit Date: Oct 15, 2024
• Publicly Available Date: Oct 22, 2024
• Journal: ERJ Open Research
• Electronic ISSN: 2312-0541
• Publisher: European Respiratory Society
• Peer Reviewed: Peer Reviewed
• Volume: 7
• Issue: 4
• Article Number: 00318-2021
• DOI: https://doi.org/10.1183/23120541.00318-2021
• Public URL: https://hull-repository.worktribe.com/output/3865572