Pd-Immobilized Schiff Base Double-Layer Macrocycle: Synthesis, Structures, Peroxidase Mimic Activity, and Antibacterial Performance

Wang, Kuiyuan; Chen, Kai; Prior, Timothy J.; Feng, Xing; Redshaw, Carl

Abstract

Di-, tri-, and tetra-aldehydes have been employed to access new [2 + 2] [2 + 3] and [2 + 4] double-layer Schiff base macrocycles. The [2 + 3] compound has been used for the immobilization of Pd and the resulting composite has been employed as a peroxidase-like mimetic using 3,3′,5,5′-tetramethylbenzidine (TMB) as the substrate; the optimum conditions together with the catalytic kinetics of the enzyme-like activity is discussed. Based on the peroxidase-like catalytic activity, the Pd@Schiff base composite was found to exhibit excellent bactericidal activity against both Escherichia coli (Gram-negative bacterium) and Staphylococcus aureus (Gram-positive bacterium) in the presence of relatively low concentrations of H2O2. Furthermore, cytotoxicity measurements illustrate the biosafety of the Pd composite. The above-mentioned findings have the potential to guide the innovation of new Pd-based composites as enzyme mimetics and antibacterial materials.

Citation

Wang, K., Chen, K., Prior, T. J., Feng, X., & Redshaw, C. (2022). Pd-Immobilized Schiff Base Double-Layer Macrocycle: Synthesis, Structures, Peroxidase Mimic Activity, and Antibacterial Performance. ACS Applied Materials & Interfaces, 14(1), 1423–1433. https://doi.org/10.1021/acsami.1c19795

• Journal Article Type: Article
• Acceptance Date: Dec 14, 2021
• Online Publication Date: Dec 30, 2021
• Publication Date: Jan 12, 2022
• Deposit Date: Jan 5, 2022
• Publicly Available Date: Dec 31, 2022
• Journal: ACS Applied Materials and Interfaces
• Print ISSN: 1944-8244
• Electronic ISSN: 1944-8252
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 14
• Issue: 1
• Pages: 1423–1433
• DOI: https://doi.org/10.1021/acsami.1c19795
• Keywords: Schiff base macrocycle; Antibacterial; Pd composite; Peroxidase-like activity
• Public URL: https://hull-repository.worktribe.com/output/3905475