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Pd-Immobilized Schiff Base Double-Layer Macrocycle: Synthesis, Structures, Peroxidase Mimic Activity, and Antibacterial Performance

Wang, Kuiyuan; Chen, Kai; Prior, Timothy J.; Feng, Xing; Redshaw, Carl

Authors

Kuiyuan Wang

Kai Chen

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Dr Tim Prior T.Prior@hull.ac.uk
Senior Lecturer in Inorganic Chemistry

Xing Feng

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Professor Carl Redshaw C.Redshaw@hull.ac.uk
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry



Abstract

Di-, tri-, and tetra-aldehydes have been employed to access new [2 + 2] [2 + 3] and [2 + 4] double-layer Schiff base macrocycles. The [2 + 3] compound has been used for the immobilization of Pd and the resulting composite has been employed as a peroxidase-like mimetic using 3,3′,5,5′-tetramethylbenzidine (TMB) as the substrate; the optimum conditions together with the catalytic kinetics of the enzyme-like activity is discussed. Based on the peroxidase-like catalytic activity, the Pd@Schiff base composite was found to exhibit excellent bactericidal activity against both Escherichia coli (Gram-negative bacterium) and Staphylococcus aureus (Gram-positive bacterium) in the presence of relatively low concentrations of H2O2. Furthermore, cytotoxicity measurements illustrate the biosafety of the Pd composite. The above-mentioned findings have the potential to guide the innovation of new Pd-based composites as enzyme mimetics and antibacterial materials.

Citation

Wang, K., Chen, K., Prior, T. J., Feng, X., & Redshaw, C. (2022). Pd-Immobilized Schiff Base Double-Layer Macrocycle: Synthesis, Structures, Peroxidase Mimic Activity, and Antibacterial Performance. ACS Applied Materials & Interfaces, 14(1), 1423–1433. https://doi.org/10.1021/acsami.1c19795

Journal Article Type Article
Acceptance Date Dec 14, 2021
Online Publication Date Dec 30, 2021
Publication Date Jan 12, 2022
Deposit Date Jan 5, 2022
Publicly Available Date Mar 29, 2024
Journal ACS Applied Materials and Interfaces
Print ISSN 1944-8244
Electronic ISSN 1944-8252
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 14
Issue 1
Pages 1423–1433
DOI https://doi.org/10.1021/acsami.1c19795
Keywords Schiff base macrocycle; Antibacterial; Pd composite; Peroxidase-like activity
Public URL https://hull-repository.worktribe.com/output/3905475

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©2021 University of Hull




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