Metabolic remodeling in the aging heart

Sample, Jessica; Cleland, John G. F.; Seymour, Anne-Marie L.

Abstract

The aim of this study was to investigate the effects of aging on the profile of myocardial substrate utilization and cardiac function using a physiological profile of substrates. Hearts from 6-, 15- and 24-month male Wistar rats were perfused in the isovolumic Langendorff mode, with physiological concentrations of C-13 labeled palmitate, and either C-13 labeled lactate or C-13 glucose. C-13-NMR glutamate isotopomer analysis was performed to determine the contribution of the different substrates to oxidative metabolism. Palmitate oxidation was significantly increased and lactate oxidation depressed in the 24-month old, senescent hearts compared to the mature 6-month hearts. This metabolic remodeling was paralleled with a marked decline in cardiac function and efficiency. These results highlight that adaptations in substrate utilization occur during senescence and may contribute to the age-related increase in the incidence of heart failure. (c) 2005 Elsevier Ltd. All rights reserved.

Citation

Sample, J., Cleland, J. G. F., & Seymour, A.-M. L. (2006). Metabolic remodeling in the aging heart. Journal of Molecular and Cellular Cardiology, 40(1), 56-63. https://doi.org/10.1016/j.yjmcc.2005.09.018

• Journal Article Type: Article
• Acceptance Date: Sep 30, 2005
• Online Publication Date: Nov 30, 2005
• Publication Date: 2006-01
• Journal: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
• Print ISSN: 0022-2828
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 40
• Issue: 1
• Pages: 56-63
• DOI: https://doi.org/10.1016/j.yjmcc.2005.09.018
• Keywords: Oxidative metabolism; Hypertrophy; 13C-NMR; Cardiac function
• Public URL: https://hull-repository.worktribe.com/output/391637
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0022282805003123?via%3Dihub#!