John G. F. Cleland
Metabolic remodeling in the aging heart
Cleland, John G. F.; Sample, Jessica; Seymour, Anne-Marie L.
Anne-Marie L. Seymour A.M.Seymour@hull.ac.uk
The aim of this study was to investigate the effects of aging on the profile of myocardial substrate utilization and cardiac function using a physiological profile of substrates. Hearts from 6-, 15- and 24-month male Wistar rats were perfused in the isovolumic Langendorff mode, with physiological concentrations of C-13 labeled palmitate, and either C-13 labeled lactate or C-13 glucose. C-13-NMR glutamate isotopomer analysis was performed to determine the contribution of the different substrates to oxidative metabolism. Palmitate oxidation was significantly increased and lactate oxidation depressed in the 24-month old, senescent hearts compared to the mature 6-month hearts. This metabolic remodeling was paralleled with a marked decline in cardiac function and efficiency. These results highlight that adaptations in substrate utilization occur during senescence and may contribute to the age-related increase in the incidence of heart failure. (c) 2005 Elsevier Ltd. All rights reserved.
Sample, J., Cleland, J. G. F., & Seymour, A. L. (2006). Metabolic remodeling in the aging heart. Journal of Molecular and Cellular Cardiology, 40(1), (56-63). doi:10.1016/j.yjmcc.2005.09.018. ISSN 0022-2828
|Journal Article Type||Article|
|Acceptance Date||Sep 30, 2005|
|Online Publication Date||Nov 30, 2005|
|Publicly Available Date|
|Journal||JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY|
|Peer Reviewed||Peer Reviewed|
|Keywords||Oxidative metabolism; Hypertrophy; 13C-NMR; Cardiac function|
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