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Metabolic remodeling in the aging heart

Sample, Jessica; Cleland, John G. F.; Seymour, Anne-Marie L.

Authors

John G. F. Cleland

Jessica Sample

Anne-Marie L. Seymour A.M.Seymour@hull.ac.uk

Abstract

The aim of this study was to investigate the effects of aging on the profile of myocardial substrate utilization and cardiac function using a physiological profile of substrates. Hearts from 6-, 15- and 24-month male Wistar rats were perfused in the isovolumic Langendorff mode, with physiological concentrations of C-13 labeled palmitate, and either C-13 labeled lactate or C-13 glucose. C-13-NMR glutamate isotopomer analysis was performed to determine the contribution of the different substrates to oxidative metabolism. Palmitate oxidation was significantly increased and lactate oxidation depressed in the 24-month old, senescent hearts compared to the mature 6-month hearts. This metabolic remodeling was paralleled with a marked decline in cardiac function and efficiency. These results highlight that adaptations in substrate utilization occur during senescence and may contribute to the age-related increase in the incidence of heart failure. (c) 2005 Elsevier Ltd. All rights reserved.

Journal Article Type Article
Publication Date 2006-01
Journal JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Print ISSN 0022-2828
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 40
Issue 1
Pages 56-63
Institution Citation Sample, J., Cleland, J. G. F., & Seymour, A. L. (2006). Metabolic remodeling in the aging heart. Journal of Molecular and Cellular Cardiology, 40(1), (56-63). doi:10.1016/j.yjmcc.2005.09.018. ISSN 0022-2828
DOI https://doi.org/10.1016/j.yjmcc.2005.09.018
Keywords Oxidative metabolism; Hypertrophy; 13C-NMR; Cardiac function
Publisher URL https://www.sciencedirect.com/science/article/pii/S0022282805003123?via%3Dihub#!