Skip to main content

Research Repository

Advanced Search

Synthesis and phototoxicity of polyethylene glycol (PEG) substituted metal-free and metallo-porphyrins: Effect of PEG chain length, coordinated metal, and axial ligand

Mewis, Ryan E.; Savoie, Huguette; Archibald, Stephen J.; Boyle, Ross W.

Authors

Ryan E. Mewis

Huguette Savoie

Ross W. Boyle R.W.Boyle@hull.ac.uk



Abstract

Treatment of 5,10,15,20-tetra(pentafluorophenyl) porphyrins with polyethylene glycol (PEG) halides and sodium sulfide is a mild and efficient route to water-soluble PEG substituted porphyrins. The method has been used to access a series of free-base and metallated PEG porphyrins, which have been investigated for photodynamic activity against Human Caucasian colon adenocarcinoma (Caco2) cells. Toxicity, in the presence and absence of light, is shown to be affected by the length of the PEG chain, nature of coordinated metal and axial ligand. © 2009 Elsevier B.V. All rights reserved.

Citation

Mewis, R. E., Savoie, H., Archibald, S. J., & Boyle, R. W. (2009). Synthesis and phototoxicity of polyethylene glycol (PEG) substituted metal-free and metallo-porphyrins: Effect of PEG chain length, coordinated metal, and axial ligand. Photodiagnosis and Photodynamic Therapy, 6(3-4), 200-206. https://doi.org/10.1016/j.pdpdt.2009.08.002

Journal Article Type Article
Acceptance Date Dec 31, 2009
Online Publication Date Oct 9, 2009
Publication Date 2009-09
Journal PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
Print ISSN 1572-1000
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 6
Issue 3-4
Pages 200-206
DOI https://doi.org/10.1016/j.pdpdt.2009.08.002
Keywords Porphyrin; PEG; Metal; Ligand
Public URL https://hull-repository.worktribe.com/output/391673
Publisher URL https://www.sciencedirect.com/science/article/pii/S157210000900129X?via%3Dihub