Jamilla A. Hussain
Development of guidelines to reduce, handle and report missing data in palliative care trials: A multi-stakeholder modified nominal group technique
Hussain, Jamilla A.; White, Ian R; Johnson, Miriam J.; Byrne, Anthony; Preston, Nancy J.; Haines, Andy; Seddon, Kathy; Peters, Tim J
Authors
Ian R White
Professor Miriam Johnson Miriam.Johnson@hull.ac.uk
Professor
Anthony Byrne
Nancy J. Preston
Andy Haines
Kathy Seddon
Tim J Peters
Abstract
Background: Missing data can introduce bias and reduce the power, precision and generalisability of study findings. Guidelines on how to address missing data are limited in scope and detail, and poorly implemented. Aim: To develop guidelines on how best to (i) reduce, (ii) handle and (iii) report missing data in palliative care clinical trials. Design: Modified nominal group technique. Setting/participants: Patient and public research partners, palliative care clinicians, trialists, methodologists and statisticians attended a 1-day workshop, following which a multi-stakeholder development group drafted the guidelines. Results: Seven main recommendations for reducing missing data, nine for handling missing data and twelve for reporting missing data were developed. The top five recommendations were: (i) train all research staff on missing data, (ii) prepare for missing data at the trial design stage, (iii) address missing data in the statistical analysis plan, (iv) collect the reasons for missing data and (v) report descriptive statistics comparing the baseline characteristics of those with missing and observed data. Reducing missing data, preparing for missing data and understanding the reasons for missing data were greater priorities for stakeholders than how to deal with missing data once they had occurred. Conclusion: Comprehensive guidelines on how to address missing data were developed by stakeholders involved in palliative care trials. Implementation of the guidelines will require endorsement of research funders and research journals.
Citation
Hussain, J. A., White, I. R., Johnson, M. J., Byrne, A., Preston, N. J., Haines, A., …Peters, T. J. (2022). Development of guidelines to reduce, handle and report missing data in palliative care trials: A multi-stakeholder modified nominal group technique. Palliative medicine, 36(1), 59-70. https://doi.org/10.1177/02692163211065597
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 6, 2021 |
Online Publication Date | Jan 17, 2022 |
Publication Date | 2022-01 |
Deposit Date | Feb 3, 2022 |
Publicly Available Date | Feb 4, 2022 |
Journal | Palliative Medicine |
Print ISSN | 0269-2163 |
Electronic ISSN | 1477-030X |
Publisher | SAGE Publications |
Peer Reviewed | Peer Reviewed |
Volume | 36 |
Issue | 1 |
Pages | 59-70 |
DOI | https://doi.org/10.1177/02692163211065597 |
Keywords | Missing data; Lost to follow up; Randomised controlled trials; Palliative care; Palliative medicine; Guideline |
Public URL | https://hull-repository.worktribe.com/output/3917019 |
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Copyright Statement
© The Author(s) 2022.
https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
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