A case-control study of polychlorinated biphenyl association with metabolic and hormonal outcomes in polycystic ovary syndrome

Brennan, Edwina; Kumar, Nitya; Drage, Daniel S.; Cunningham, Thomas K.; Sathyapalan, Thozhukat; Mueller, Jochen F.; Atkin, Stephen L.

Abstract

Polychlorinated biphenyls (PCBs) are a class of environmental pollutants with a long half-life that sequester in fat. Women with polycystic ovarian syndrome (PCOS) may represent a sensitive subgroup to endogenous exposure to PCBs because of associated weight gain. Seven PCB congeners were compared in age, ethnicity, and BMI matched women with (n = 29) and without (n = 30) PCOS and related to metabolic outcomes, and steroid and thyroid hormone levels. PCB118, PCB138, PCB153, and PCB180 were detected in all serum samples but geometric mean did not differ between cases and controls. PCBs correlated with increasing concentrations of each other (p <.01), increasing age (p <.01) and decreasing lneGFR (p <.05). lnPCB118 correlated with increasing Free-T4 (p =.028). lnPCB158, lnPCB180, and ln∑PCB correlated with increasing lnSHBG (p <.044). In regression modeling, although not significant, PCB118 positively associated with lnSHBG in controls (p =.0504) but not in cases; estradiol inversely associated with PCB138 in controls (p =.055) and ∑PCB in cases (p =.051). No significant associations were observed between metabolic endpoints, and steroid and thyroid hormone levels. The results presented do not suggest the PCOS cases in this cohort are at adverse risk compared to age, ethnicity, and BMI matched controls.

Citation

Brennan, E., Kumar, N., Drage, D. S., Cunningham, T. K., Sathyapalan, T., Mueller, J. F., & Atkin, S. L. (2022). A case-control study of polychlorinated biphenyl association with metabolic and hormonal outcomes in polycystic ovary syndrome. Journal of Environmental Science and Health , Part C: Toxicology and Carcinogenesis, 40(1), 86-105. https://doi.org/10.1080/26896583.2022.2043135

• Journal Article Type: Article
• Acceptance Date: Feb 12, 2022
• Online Publication Date: Mar 14, 2022
• Publication Date: 2022
• Deposit Date: Aug 29, 2022
• Publicly Available Date: Mar 15, 2023
• Journal: Journal of Environmental Science and Health, Part C: Toxicology and Carcinogenesis
• Print ISSN: 1059-0501
• Electronic ISSN: 1532-4095
• Publisher: Taylor & Francis
• Peer Reviewed: Peer Reviewed
• Volume: 40
• Issue: 1
• Pages: 86-105
• DOI: https://doi.org/10.1080/26896583.2022.2043135
• Keywords: Polycystic ovarian syndrome; Endocrine disrupters; Polychlorinated biphenyls
• Public URL: https://hull-repository.worktribe.com/output/3960479