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Regulatory T cells: what role do they play in antitumor immunity in patients with head and neck cancer?

Alhamarneh, Osama; Amarnath, Shoba M. P.; Stafford, Nicholas D.; Greenman, John

Authors

Osama Alhamarneh

Shoba M. P. Amarnath

Nicholas D. Stafford



Abstract

Advances in the treatment modalities for head and neck squamous cell carcinoma (HNSCC) over the last 20 years involving surgery, radiotherapy, chemotherapy, and immunotherapy are not fully reflected in increases in the 5-year survival rates, mainly due to locoregional recurrences and to a lesser extent, distant metastasis. This can, in part, be attributed to the fact that HNSCC induces severe depression of a patient's immune system. Recent advances in understanding the complex host-tumor interactions have led to the identification of a distinct suppressor cell population known as regulatory T cells that play a crucial role in maintaining T-cell tolerance to self-antigens. Here, we present a critical review of our understanding of the involvement of regulatory T cells in controlling the T-cell immune response in tumor occurrence and progression in HNSCC with an emphasis on current and future immunotherapeutic approaches involving regulatory T cells.

Citation

Alhamarneh, O., Amarnath, S. M. P., Stafford, N. D., & Greenman, J. (2008). Regulatory T cells: what role do they play in antitumor immunity in patients with head and neck cancer?. Head & neck, 30(2), 251-261. doi:10.1002/hed.20739

Journal Article Type Review
Acceptance Date Feb 28, 2008
Online Publication Date Jan 9, 2008
Publication Date 2008-02
Publicly Available Date
Journal HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Print ISSN 1043-3074
Electronic ISSN 1097-0347
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 30
Issue 2
Pages 251-261
DOI https://doi.org/10.1002/hed.20739
Keywords Otorhinolaryngology
Public URL https://hull-repository.worktribe.com/output/396103