Production of deuterium labelled (−)-epicatechin in a microreactor

Peng, Wei Min; Betts, Jonathan W.; Kitney, Stuart P.; Fu, Yiton; Peng, Wei-Min; Kelly, Stephen M.; Haswell, Stephen J.

Abstract

Green tea catechins have been reported to have multiple health benefits. To understand their metabolic and toxicological interactions in the human body studies need to be undertaken using stable isotope labelled compounds, but they can be time consuming and expensive. Using microreactor technology labelling catechins could be produced more quickly and at a reduced cost. This research reports on a 2-step synthesis of deuterium labelled epicatechin developed using microreactor technology for the production.

Citation

Betts, J. W., Kitney, S. P., Fu, Y., Peng, W., Kelly, S. M., & Haswell, S. J. (2011). Production of deuterium labelled (−)-epicatechin in a microreactor. Chemical Engineering Journal, 167(2-3), 545-547. https://doi.org/10.1016/j.cej.2010.08.093

• Journal Article Type: Article
• Acceptance Date: Aug 31, 2010
• Online Publication Date: Oct 23, 2010
• Publication Date: Mar 1, 2011
• Journal: CHEMICAL ENGINEERING JOURNAL
• Print ISSN: 1385-8947
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 167
• Issue: 2-3
• Pages: 545-547
• DOI: https://doi.org/10.1016/j.cej.2010.08.093
• Keywords: Microreactor; Epicatechin; Polyphenols; Deuterium; Labelling
• Public URL: https://hull-repository.worktribe.com/output/396321
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1385894710010053?via%3Dihub