Production of deuterium labelled (−)-epicatechin in a microreactor

Peng, Wei Min; Betts, Jonathan W.; Kitney, Stuart P.; Fu, Yiton; Peng, Wei-Min; Kelly, Stephen M.; Haswell, Stephen J.

doi:10.1016/j.cej.2010.08.093

Production of deuterium labelled (−)-epicatechin in a microreactor

Peng, Wei Min; Betts, Jonathan W.; Kitney, Stuart P.; Fu, Yiton; Peng, Wei-Min; Kelly, Stephen M.; Haswell, Stephen J.

Authors

Wei Min Peng

Jonathan W. Betts

Stuart P. Kitney

Yiton Fu

Wei-Min Peng

Stephen M. Kelly

Stephen J. Haswell

Abstract

Green tea catechins have been reported to have multiple health benefits. To understand their metabolic and toxicological interactions in the human body studies need to be undertaken using stable isotope labelled compounds, but they can be time consuming and expensive. Using microreactor technology labelling catechins could be produced more quickly and at a reduced cost. This research reports on a 2-step synthesis of deuterium labelled epicatechin developed using microreactor technology for the production.

Citation

Betts, J. W., Kitney, S. P., Fu, Y., Peng, W.-M., Kelly, S. M., & Haswell, S. J. (2011). Production of deuterium labelled (−)-epicatechin in a microreactor. Chemical Engineering Journal, 167(2-3), 545-547. https://doi.org/10.1016/j.cej.2010.08.093

Journal Article Type	Article
Acceptance Date	Aug 31, 2010
Online Publication Date	Oct 23, 2010
Publication Date	Mar 1, 2011
Journal	CHEMICAL ENGINEERING JOURNAL
Print ISSN	1385-8947
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	167
Issue	2-3
Pages	545-547
DOI	https://doi.org/10.1016/j.cej.2010.08.093
Keywords	Microreactor; Epicatechin; Polyphenols; Deuterium; Labelling
Public URL	https://hull-repository.worktribe.com/output/396321
Publisher URL	https://www.sciencedirect.com/science/article/pii/S1385894710010053?via%3Dihub