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Production of deuterium labelled (−)-epicatechin in a microreactor

Peng, Wei Min; Betts, Jonathan W.; Kitney, Stuart P.; Fu, Yiton; Peng, Wei-Min; Kelly, Stephen M.; Haswell, Stephen J.


Wei Min Peng

Jonathan W. Betts

Stuart P. Kitney

Yiton Fu

Wei-Min Peng

Stephen M. Kelly

Stephen J. Haswell


Green tea catechins have been reported to have multiple health benefits. To understand their metabolic and toxicological interactions in the human body studies need to be undertaken using stable isotope labelled compounds, but they can be time consuming and expensive. Using microreactor technology labelling catechins could be produced more quickly and at a reduced cost. This research reports on a 2-step synthesis of deuterium labelled epicatechin developed using microreactor technology for the production.


Betts, J. W., Kitney, S. P., Fu, Y., Peng, W., Kelly, S. M., & Haswell, S. J. (2011). Production of deuterium labelled (−)-epicatechin in a microreactor. Chemical Engineering Journal, 167(2-3), 545-547.

Journal Article Type Article
Acceptance Date Aug 31, 2010
Online Publication Date Oct 23, 2010
Publication Date Mar 1, 2011
Print ISSN 1385-8947
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 167
Issue 2-3
Pages 545-547
Keywords Microreactor; Epicatechin; Polyphenols; Deuterium; Labelling
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