Skip to main content

Antibacterial effects of theaflavin and synergy with epicatechin against clinical isolates of Acinetobacter baumannii and Stenotrophomonas maltophilia

Betts, J. W.; Kelly, S. M.; Haswell, S. J.

Authors

J. W. Betts

S. J. Haswell



Abstract

Stenotrophomonas maltophilia and Acinetobacter baumannii are recognised as important nosocomial pathogens; however, due to their intrinsic resistance to multiple antibiotics, treatment options are limited. Polyphenols from black tea have been shown to possess antibacterial action. In this study, the antibacterial effects of various concentrations of theaflavin as well as combinations of theaflavin and epicatechin were determined using the disk diffusion assay. The results showed strong antibacterial activity of theaflavin against eight clinical isolates of S. maltophilia and A. baumannii. Significant synergy (P ≤ 0.05) was also observed between theaflavin and epicatechin against all isolates. Although the mechanisms for this activity and synergy are not well understood, the clinical potential is clear and further research is recommended to determine the modes of action.

Journal Article Type Article
Publication Date 2011-11
Journal INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Print ISSN 0924-8579
Electronic ISSN 1872-7913
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 38
Issue 5
Pages 421-425
APA6 Citation Betts, J. W., Kelly, S. M., & Haswell, S. J. (2011). Antibacterial effects of theaflavin and synergy with epicatechin against clinical isolates of Acinetobacter baumannii and Stenotrophomonas maltophilia. International journal of antimicrobial agents, 38(5), 421-425. https://doi.org/10.1016/j.ijantimicag.2011.07.006
DOI https://doi.org/10.1016/j.ijantimicag.2011.07.006
Keywords Antibacterial; Theaflavin; Epicatechin; Polyphenol; Synergy; Acinetobacter baumannii; Stenotrophomonas maltophilia
Publisher URL https://www.sciencedirect.com/science/article/pii/S0924857911003153?via%3Dihub#!
;