Investigating the diagnostic utility of high-resolution oesophageal manometry in patients with refractory respiratory symptoms

Sykes, Dominic L.; Crooks, Michael G.; Hart, Simon P.; Jackson, Warren; Gallagher, John; Morice, Alyn H.

Abstract

Background: The interaction between the respiratory and gastrointestinal systems, and the role of the latter in the development of respiratory pathology, has been examined with a focus on gastro-oesophageal reflux disease (GORD). However, little data exists examining the link between oesophageal motility and respiratory disease. Aims and objectives: In this study, we examined patterns in oesophageal motility using high-resolution oesophageal manometry (HROM) in patients with refractory respiratory symptoms. Methods: Data were collected retrospectively for all patients that were investigated using HROM at a single centre for refractory respiratory symptoms between January 1st, 2011–December 1st, 2021. Patients were selected for investigation based on airway reflux symptoms, measured by the Hull Airways Reflux Questionnaire (HARQ). Results: 441 patients were investigated with HROM (64% female, mean age = 56.5 [SD = 13.9]). The commonest diagnoses of these patients were Chronic Cough (77%, n = 339), Asthma (10%, n = 44), and Interstitial Lung Disease (7%, n = 29). The prevalence of oesophageal dysmotility was 66% in our cohort. Those with oesophageal dysmotility had significantly higher HARQ scores than those with normal motility (40.6 vs 35.3, p < 0.001) and there was a significant inverse correlation between HARQ scores and distal contractile integral (DCI), a measure of oesophageal contractility. Conclusions: Two-thirds of patients with refractory respiratory symptoms were found to have oesophageal dysmotility on HROM. These findings suggest motility disorders of the oesophagus may contribute to the development and progression of respiratory disease. This study highlights the need for further prospective study of the relationship between oesophageal dysmotility and respiratory disease.

Citation

Sykes, D. L., Crooks, M. G., Hart, S. P., Jackson, W., Gallagher, J., & Morice, A. H. (2022). Investigating the diagnostic utility of high-resolution oesophageal manometry in patients with refractory respiratory symptoms. Respiratory medicine, 202, Article 106985. https://doi.org/10.1016/j.rmed.2022.106985

• Journal Article Type: Article
• Acceptance Date: Sep 5, 2022
• Online Publication Date: Sep 9, 2022
• Publication Date: 2022-10
• Deposit Date: Sep 26, 2022
• Publicly Available Date: Oct 1, 2022
• Journal: Respiratory Medicine
• Print ISSN: 0954-6111
• Electronic ISSN: 1532-3064
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 202
• Article Number: 106985
• DOI: https://doi.org/10.1016/j.rmed.2022.106985
• Keywords: Pulmonary and Respiratory Medicine
• Public URL: https://hull-repository.worktribe.com/output/4084289