The relationship between subchondral bone cysts and cartilage health in the Tibiotalar joint: A finite element analysis

Talbott, Harriet G.; Wilkins, Richard A.; Redmond, Anthony C.; Brockett, Claire L.; Mengoni, Marlène

Abstract

Background: Subchondral bone cysts are a common presentation in ankle haemarthropathy. The relationship with ankle joint health has however not previously been investigated. The aim of this study was to assess the influence of subchondral bone cysts of differing shapes, volumes and depths on joint health. Methods: Chronologically sequential Magnetic Resonance imaging scans of four hemophilic ankles with subchondral bone cysts present (N = 18) were used to build patient specific finite element models under two cystic conditions to assess their influence on cartilage contact pressures. Variables such as location, volume and depth were considered individually, to investigate whether certain cystic conditions may be more detrimental to cartilage health. Findings: Significant quantifiable contact redistribution was seen in the presence of subchondral bone cysts and this redistribution reflected the shape and size of the cysts, however, with the presence of cysts in both bones in 10 of the 18 cases a direct relationship to volume could not be correlated. Interpretation: This work demonstrated a redistribution of contact pressures in the presence of subchondral bone cysts. This alteration to loading history could be linked to cartilage degeneration due to the biological response to abnormal loading.

Citation

Talbott, H. G., Wilkins, R. A., Redmond, A. C., Brockett, C. L., & Mengoni, M. (2022). The relationship between subchondral bone cysts and cartilage health in the Tibiotalar joint: A finite element analysis. Clinical biomechanics, 99, Article 105745. https://doi.org/10.1016/j.clinbiomech.2022.105745

• Journal Article Type: Article
• Acceptance Date: Aug 22, 2022
• Online Publication Date: Aug 30, 2022
• Publication Date: 2022-10
• Deposit Date: Oct 5, 2022
• Publicly Available Date: Oct 5, 2022
• Journal: Clinical Biomechanics
• Print ISSN: 0268-0033
• Electronic ISSN: 1879-1271
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 99
• Article Number: 105745
• DOI: https://doi.org/10.1016/j.clinbiomech.2022.105745
• Keywords: Finite element analysis; Subchondral bone cysts; Hemophilia; Ankle joint; Contact pressure
• Public URL: https://hull-repository.worktribe.com/output/4087356