Dr Harriet Talbott H.Talbott@hull.ac.uk
Medical Engineering Programme Director; Lecturer in Medical Engineering
Incorporating pathological gait into patient-specific finite element models of the haemophilic ankle
Talbott, Harriet G.; Wilkins, Richard A.; Brockett, Claire L.; Mengoni, Marlène
Authors
Richard A. Wilkins
Claire L. Brockett
Marlène Mengoni
Abstract
Haemarthrosis is an inherent clinical feature of haemophilia, a disease characterised by an absence or reduction in clotting proteins. Patients with severe haemophilia experience joint bleeding leading to blood-induced ankle arthropathy (haemarthropathy). Altered biomechanics of the ankle have been reported in people with haemophilia; however, the consequence of this on joint health is little understood. The aim of this study was to assess the changes in joint contact due to haemophilia disease-specific gait features using patient-specific modelling, to better understand the link between biomechanics and joint outcomes. Four, image-based, finite element models of haemophilic ankles were simulated through consecutive events in the stance phase of gait, using both patient-specific and healthy control group (n = 36) biomechanical inputs. One healthy control FE model was simulated through the healthy control stance phase of the gait cycle for a point of comparison. The method developed allowed cartilage contact mechanics to be assessed throughout the loading phase of the gait cycle. This showed areas of increased contact pressure in the medial and lateral regions of the talar dome, which may be linked to collapse in these regions. This method may allow the relationship between structure and function in the tibiotalar joint to be better understood.
Citation
Talbott, H. G., Wilkins, R. A., Brockett, C. L., & Mengoni, M. (2024). Incorporating pathological gait into patient-specific finite element models of the haemophilic ankle. Biomechanics and Modeling in Mechanobiology, https://doi.org/10.1007/s10237-024-01857-z
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Apr 28, 2024 |
| Online Publication Date | May 20, 2024 |
| Publication Date | 2024 |
| Deposit Date | Jul 22, 2024 |
| Publicly Available Date | Jul 23, 2024 |
| Journal | Biomechanics and Modeling in Mechanobiology |
| Print ISSN | 1617-7940 |
| Publisher | Springer Verlag |
| Peer Reviewed | Peer Reviewed |
| DOI | https://doi.org/10.1007/s10237-024-01857-z |
| Keywords | Tibiotalar; Patient specific; Biomechanics; Finite element analysis; Contact mechanics; Haemophilia |
| Public URL | https://hull-repository.worktribe.com/output/4674049 |
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Copyright Statement
© The Author(s) 2024.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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