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Stimulus reconstruction from a Hodgkin-Huxley neural response: A numerical solution

Sarangdhar, M; Kambhampati, C


M Sarangdhar

C Kambhampati


Neural responses are the fundamental expressions of any neural activity. Information carried by a neural response is determined by the nature of a neural activity. In majority of cases the underlying stimulus that triggers it remains largely unknown. Previous studies to reconstruct the stimulus from a neural response show that the high non-linearity of neural dynamics renders inversion of a neuron a challenging task. This paper presents a numerical solution rather than an analytical one to reconstruct stimuli from Hodgkin-Huxley neural responses. The stimulus is reconstructed by first retrieving the maximal conductances of the ionic channels and then solving the Hodgkin-Huxley equations for the stimulus. The results show that the reconstructed stimulus matches the original stimulus to a high degree of accuracy. In addition, this reconstruction approach also retrieves the neural dynamics for which an analytical solution does not currently exist. Constant-current and periodic stimuli are shown to be accurately reconstructed using this approach.

Start Date Jun 30, 2010
Publication Date Dec 31, 2010
Journal WCE 2010 - World Congress on Engineering 2010
Volume 1
Pages 627 - 632
Book Title Proceedings of the World Congress on Engineering
ISBN 9789881701299
APA6 Citation Sarangdhar, M., & Kambhampati, C. (2010). Stimulus reconstruction from a Hodgkin-Huxley neural response: A numerical solution. In Proceedings of the World Congress on Engineering, 627 - 632
Keywords Stimulus reconstruction; Hodgkin-Huxley neuron; Neural response inverse; Neural dynamics retrieval