Stimulus reconstruction from a Hodgkin-Huxley neural response: A numerical solution

Sarangdhar, M; Kambhampati, C

Abstract

Neural responses are the fundamental expressions of any neural activity. Information carried by a neural response is determined by the nature of a neural activity. In majority of cases the underlying stimulus that triggers it remains largely unknown. Previous studies to reconstruct the stimulus from a neural response show that the high non-linearity of neural dynamics renders inversion of a neuron a challenging task. This paper presents a numerical solution rather than an analytical one to reconstruct stimuli from Hodgkin-Huxley neural responses. The stimulus is reconstructed by first retrieving the maximal conductances of the ionic channels and then solving the Hodgkin-Huxley equations for the stimulus. The results show that the reconstructed stimulus matches the original stimulus to a high degree of accuracy. In addition, this reconstruction approach also retrieves the neural dynamics for which an analytical solution does not currently exist. Constant-current and periodic stimuli are shown to be accurately reconstructed using this approach.

Citation

Sarangdhar, M., & Kambhampati, C. (2010). Stimulus reconstruction from a Hodgkin-Huxley neural response: A numerical solution. In Proceedings of the World Congress on Engineering (627 - 632)

• Conference Name: World Congress on Engineering 2010
• Start Date: Jun 30, 2010
• End Date: Jul 2, 2010
• Acceptance Date: Dec 31, 2010
• Publication Date: Dec 31, 2010
• Journal: WCE 2010 - World Congress on Engineering 2010
• Volume: 1
• Pages: 627 - 632
• Book Title: Proceedings of the World Congress on Engineering
• ISBN: 9789881701299
• Keywords: Stimulus reconstruction; Hodgkin-Huxley neuron; Neural response inverse; Neural dynamics retrieval
• Public URL: https://hull-repository.worktribe.com/output/409693