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Stimulus reconstruction from a Hodgkin-Huxley neural response: A numerical solution

Sarangdhar, M; Kambhampati, C

Authors

M Sarangdhar



Abstract

Neural responses are the fundamental expressions of any neural activity. Information carried by a neural response is determined by the nature of a neural activity. In majority of cases the underlying stimulus that triggers it remains largely unknown. Previous studies to reconstruct the stimulus from a neural response show that the high non-linearity of neural dynamics renders inversion of a neuron a challenging task. This paper presents a numerical solution rather than an analytical one to reconstruct stimuli from Hodgkin-Huxley neural responses. The stimulus is reconstructed by first retrieving the maximal conductances of the ionic channels and then solving the Hodgkin-Huxley equations for the stimulus. The results show that the reconstructed stimulus matches the original stimulus to a high degree of accuracy. In addition, this reconstruction approach also retrieves the neural dynamics for which an analytical solution does not currently exist. Constant-current and periodic stimuli are shown to be accurately reconstructed using this approach.

Citation

Sarangdhar, M., & Kambhampati, C. (2010). Stimulus reconstruction from a Hodgkin-Huxley neural response: A numerical solution. In Proceedings of the World Congress on Engineering, 627 - 632

Conference Name World Congress on Engineering 2010
Start Date Jun 30, 2010
End Date Jul 2, 2010
Acceptance Date Dec 31, 2010
Publication Date Dec 31, 2010
Journal WCE 2010 - World Congress on Engineering 2010
Volume 1
Pages 627 - 632
Book Title Proceedings of the World Congress on Engineering
ISBN 9789881701299
Keywords Stimulus reconstruction; Hodgkin-Huxley neuron; Neural response inverse; Neural dynamics retrieval
Public URL https://hull-repository.worktribe.com/output/409693