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Preparation of pelargonic acid vesicles and sustained drug release

Wang, Zhimei; Zhang, Yuehuan; Chen, Qing; Xiao, Xin; Redshaw, Carl

Authors

Zhimei Wang

Yuehuan Zhang

Qing Chen

Xin Xiao

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Professor Carl Redshaw C.Redshaw@hull.ac.uk
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry



Abstract

This study has selected the medium-chain saturated fatty acid pelargonic acid as the raw material for the first time, and added the surface catalyst Tween-80 to the aqueous solution to form pelargonic acid-Tween-80 composite vesicles by a surface tension method. The compound vesicle was used to encapsulate five heterocyclic drugs (ceftazolin sodium, chlorpromazine hydrochloride, gemcitabine hydrochloride, metronidazole, and isoniazid), all of which have disadvantages when used directly, and the effects of the vesicles on the five kinds of drugs was evaluated in terms of encapsulation rate and the in vitro sustained-release in a simulated artificial intestinal fluid environment. The results revealed that the pelargonic acid-Tween-80 composite vesicles exhibit an encapsulation efficiency above 45%, and that the encapsulated drugs achieve a cumulative release effect of 6-10 hours in a simulated artificial intestinal fluid environment, and the cumulative release rate is above 35%. This study proves that pelargonic acid-Tween-80 composite vesicles can be used as a carrier for encapsulated drugs, and this can extend the time of action of the drugs. This research illustrates the potential for application of pelargonic acid in the field of medicine.

Citation

Wang, Z., Zhang, Y., Chen, Q., Xiao, X., & Redshaw, C. (2022). Preparation of pelargonic acid vesicles and sustained drug release. Canadian Journal of Chemistry, https://doi.org/10.1139/cjc-2022-0075

Journal Article Type Article
Acceptance Date Oct 7, 2022
Online Publication Date Oct 28, 2022
Publication Date 2022
Deposit Date Nov 1, 2022
Publicly Available Date Nov 2, 2022
Journal Canadian Journal of Chemistry
Print ISSN 0008-4042
Electronic ISSN 1480-3291
Publisher NRC Research Press (Canadian Science Publishing)
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1139/cjc-2022-0075
Keywords Organic Chemistry; General Chemistry; Catalysis
Public URL https://hull-repository.worktribe.com/output/4110793

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