Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions
Rivas, Charlotte; Stasiuk, Graeme J.; Sae-Heng, Myra; Long, Nicholas J.
Graeme J. Stasiuk
Nicholas J. Long
A series of gadolinium complexes were synthesised in order to test the design of dual-modal probes that display a change in fluorescence or relaxivity response upon binding of zinc. A dansyl-DO3ATA gadolinium complex [GdL1] displayed an increase and a slight blue-shift in fluorescence in the presence of zinc; however, a decrease in relaxation rate was observed. Consequently, the ability of the well-known zinc chelator, BPEN, was assessed for relaxivity response when conjugated to the gadolinium chelate. The success of this probe [GdL2], lead to the inclusion of the same zinc-probing moiety alongside a longer wavelength emitting fluorophore, rhodamine [GdL3], to arrive at the final iteration of these first generation dual-modal zinc-sensing probes. The compounds give insight into the design protocols required for the successful imaging of zinc ions.
|Journal Article Type||Article|
|Publication Date||Jan 1, 2015|
|Publisher||Royal Society of Chemistry|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Rivas, C., Stasiuk, G. J., Sae-Heng, M., & Long, N. J. (2015). Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions. Dalton transactions : an international journal of inorganic chemistry / RSoC, 44(11), 4976-4985. doi:10.1039/c4dt02981j|
|Keywords||Dual mode imaging|
|Copyright Statement||©2016 the Authors|
|Additional Information||This is the authors accepted manuscript of an article published in Dalton transactions, 2014, v.44 issue 11.|
©2016 the Authors
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