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Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions

Rivas, Charlotte; Stasiuk, Graeme J.; Sae-Heng, Myra; Long, Nicholas J.

Authors

Charlotte Rivas

Graeme J. Stasiuk

Myra Sae-Heng

Nicholas J. Long



Abstract

A series of gadolinium complexes were synthesised in order to test the design of dual-modal probes that display a change in fluorescence or relaxivity response upon binding of zinc. A dansyl-DO3ATA gadolinium complex [GdL1] displayed an increase and a slight blue-shift in fluorescence in the presence of zinc; however, a decrease in relaxation rate was observed. Consequently, the ability of the well-known zinc chelator, BPEN, was assessed for relaxivity response when conjugated to the gadolinium chelate. The success of this probe [GdL2], lead to the inclusion of the same zinc-probing moiety alongside a longer wavelength emitting fluorophore, rhodamine [GdL3], to arrive at the final iteration of these first generation dual-modal zinc-sensing probes. The compounds give insight into the design protocols required for the successful imaging of zinc ions.

Journal Article Type Article
Publication Date Jan 1, 2015
Journal Dalton transactions
Print ISSN 1477-9226
Electronic ISSN 1477-9234
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 44
Issue 11
Pages 4976-4985
APA6 Citation Rivas, C., Stasiuk, G. J., Sae-Heng, M., & Long, N. J. (2015). Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions. Dalton transactions : an international journal of inorganic chemistry / RSoC, 44(11), 4976-4985. doi:10.1039/c4dt02981j
DOI https://doi.org/10.1039/c4dt02981j
Keywords Dual mode imaging
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2015/DT/c4dt02981j#!divAbstract
Copyright Statement ©2016 the Authors
Additional Information This is the authors accepted manuscript of an article published in Dalton transactions, 2014, v.44 issue 11.

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