Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions

Rivas, Charlotte; Stasiuk, Graeme J.; Sae-Heng, Myra; Long, Nicholas J.

Abstract

A series of gadolinium complexes were synthesised in order to test the design of dual-modal probes that display a change in fluorescence or relaxivity response upon binding of zinc. A dansyl-DO3ATA gadolinium complex [GdL1] displayed an increase and a slight blue-shift in fluorescence in the presence of zinc; however, a decrease in relaxation rate was observed. Consequently, the ability of the well-known zinc chelator, BPEN, was assessed for relaxivity response when conjugated to the gadolinium chelate. The success of this probe [GdL2], lead to the inclusion of the same zinc-probing moiety alongside a longer wavelength emitting fluorophore, rhodamine [GdL3], to arrive at the final iteration of these first generation dual-modal zinc-sensing probes. The compounds give insight into the design protocols required for the successful imaging of zinc ions.

Citation

Rivas, C., Stasiuk, G. J., Sae-Heng, M., & Long, N. J. (2015). Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions. Dalton Transactions : an international journal of inorganic chemistry, 44(11), 4976-4985. https://doi.org/10.1039/c4dt02981j

• Journal Article Type: Article
• Acceptance Date: Dec 18, 2014
• Online Publication Date: Dec 18, 2014
• Publication Date: Jan 1, 2015
• Deposit Date: Feb 23, 2016
• Publicly Available Date: Feb 23, 2016
• Journal: Dalton transactions
• Print ISSN: 1477-9226
• Electronic ISSN: 1477-9234
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 44
• Issue: 11
• Pages: 4976-4985
• DOI: https://doi.org/10.1039/c4dt02981j
• Keywords: Dual mode imaging
• Public URL: https://hull-repository.worktribe.com/output/411246
• Publisher URL: http://pubs.rsc.org/en/Content/ArticleLanding/2015/DT/c4dt02981j#!divAbstract
• Additional Information: This is the authors accepted manuscript of an article published in Dalton transactions, 2014, v.44 issue 11.
• Contract Date: Feb 23, 2016