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Recent Advances in Lung Cancer Therapy Based on Nanomaterials: A Review

Gholami, Leila; Ivari, Jalil Rouhani; Nasab, Niloofar Khandan; Oskuee, Reza Kazemi; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Authors

Leila Gholami

Jalil Rouhani Ivari

Niloofar Khandan Nasab

Reza Kazemi Oskuee

Amirhossein Sahebkar



Abstract

Lung cancer is one of the commonest cancers with a significant mortality rate for both genders, particularly in men. Lung cancer is recognized as one of the leading causes of death worldwide, which threatens the lives of over 1.6 million people every day. Although cancer is the leading cause of death in industrialized countries, conventional an-ticancer medications are unlikely to increase patients' life expectancy and quality of life significantly. In recent years, there are significant advances in the development and applications of nanotechnology in cancer treatment. The superiority of nanostructured approaches is that they act more selectively than traditional agents. This progress led to the development of a novel field of cancer treatment known as nanomedicine. Various formulations based on nanocarriers, including lipids, polymers, liposomes, nanoparticles and dendrimers have opened new horizons in lung cancer therapy. The application and expan-sion of nano-agents lead to an exciting and challenging research era in pharmaceutical science, especially for the delivery of emerging anti-cancer agents. The objective of this review is to discuss the recent advances in three types of nanoparticle formulations for lung cancer treatments modalities, including liposomes, polymeric micelles, and den-drimers for efficient drug delivery. Afterward, we have summarized the promising clinical data on nanomaterials based therapeutic approaches in ongoing clinical studies.

Citation

Gholami, L., Ivari, J. R., Nasab, N. K., Oskuee, R. K., Sathyapalan, T., & Sahebkar, A. (2023). Recent Advances in Lung Cancer Therapy Based on Nanomaterials: A Review. Current medicinal chemistry, 30(3), 335-355. https://doi.org/10.2174/0929867328666210810160901

Journal Article Type Review
Acceptance Date Jan 1, 2022
Online Publication Date Jan 4, 2022
Publication Date Jan 18, 2023
Deposit Date Feb 18, 2023
Publicly Available Date Feb 20, 2023
Journal Current Medicinal Chemistry
Print ISSN 0929-8673
Publisher Bentham Science Publishers
Peer Reviewed Peer Reviewed
Volume 30
Issue 3
Pages 335-355
DOI https://doi.org/10.2174/0929867328666210810160901
Keywords Lung cancer; Treatment; Nanocarriers; Drug delivery; Nanomedicine; Nanomaterials
Public URL https://hull-repository.worktribe.com/output/4163190
This output contributes to the following UN Sustainable Development Goals:

SDG 3 - Good Health and Well-Being

Ensure healthy lives and promote well-being for all at all ages

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