Jean Luc Dubois-Randé
Prevalence of, associations with, and prognostic value of tricuspid annular plane systolic excursion (TAPSE) among out-patients referred for the evaluation of heart failure
Dubois-Randé, Jean Luc; Kallvikbacka-Bennett, Anna; Dubos-Rande, Jean-Luc; Damy, Thibaud; Cleland, John G.F.; Kallvikbacka-Bennett, Anne; Goode, Kevin; Khaleva, Olga; Lewinter, Christian; Hobkirk, James; Clark, Andrew; Nikitin, Nikolay P.; Dubois-Randé, Jean-Luc; Hittinger, Luc; Clark, Andrew L.; Cleland, John G. F.
John G.F. Cleland
Anne Kallvikbacka-Bennett A.Kallvikbacka-Bennett@hull.ac.uk
Dr Kevin Goode K.M.Goode@hull.ac.uk
Research Systems Project Manager / Business Analyst
Dr James Hobkirk J.Hobkirk@hull.ac.uk
Lecturer in Physiology
Andrew Clark A.L.Clark@hull.ac.uk
Nikolay P. Nikitin
Andrew L. Clark
John G. F. Cleland
Background: Prevalence, predictors, and prognostic value of right ventricular (RV) function measured by the tricuspid annular plane systolic excursion (TAPSE) in patients with chronic heart failure (CHF) symptoms with a broad range of left ventricular ejection fraction (LVEF) are unknown. Methods and Results: Of 1,547 patients, mean (±SD) age was 71 ± 11 years, 48% were women, median (interquartile range [IQR]) TAPSE was 18.5 (14.0-22.7) mm, mean LVEF was 47 ± 16%, 47% had LVEF ≤45% and 67% were diagnosed with CHF, defined as systolic (S-HF) if LVEF was ≤45% and as heart failure with preserved ejection fraction (HFPEF) if LVEF was > 45% and treated with a loop diuretic. During a median (IQR) follow-up of 63 (41-75) months, mortality was 34%. In multivariable analysis, increasing age, N-terminal pro-B-type natriuretic peptide (NT-proBNP), New York Heart Association functional class, right atrial volume index, and transtricuspid pressure gradient; lower TAPSE, diastolic blood pressure, and hemoglobin; and atrial fibrillation (AF) or COPD were associated with an adverse prognosis. Receiver operating characteristic curve analysis identified a TAPSE of 15.9 mm as the best prognostic threshold (P =.0001); 47% of S-HF and 20% of HFPEF had a TAPSE of < 15.9 mm. The main associations with a TAPSE < 15.9 mm were higher NT-proBNP, presence of atrial fibrillation and presence of LV systolic dysfunction. Conclusions: In patients with CHF, low values for TAPSE are common, especially in those with reduced LVEF. TAPSE, unlike LVEF, was an independent predictor of outcome. © 2012 Elsevier Inc. All rights reserved.
Damy, T., Kallvikbacka-Bennett, A., Goode, K., Khaleva, O., Lewinter, C., Hobkirk, J., …Cleland, J. G. F. (2012). Prevalence of, associations with, and prognostic value of tricuspid annular plane systolic excursion (TAPSE) among out-patients referred for the evaluation of heart failure. Journal of cardiac failure, 18(3), 216-225. https://doi.org/10.1016/j.cardfail.2011.12.003
|Journal Article Type||Article|
|Acceptance Date||Dec 14, 2011|
|Online Publication Date||Jan 26, 2012|
|Journal||JOURNAL OF CARDIAC FAILURE|
|Peer Reviewed||Peer Reviewed|
|Keywords||Heart failure; Prognosis; Right ventricle; Echocardiography; TAPSE|
This file is under embargo due to copyright reasons.
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