Victoria L. Green
Serum IL10, IL12 and circulating CD4+CD25high T regulatory cells in relation to long-term clinical outcome in head and neck squamous cell carcinoma patients
Green, Victoria L.; Irune, Ekpemi; Prasai, Amit; Alhamarneh, Osama; Greenman, John; Stafford, Nicholas D.
Professor John Greenman J.Greenman@hull.ac.uk
Professor of Tumour Immunology
Nicholas D. Stafford
IL10, but not IL12 or T regulatory cells in the circulation of newly presenting, pre-treatment head and neck squamous cell carcinoma (HNSCC) patients, has been shown previously to be related to survival over a mean follow-up period of 15 months. Here, we followed the same patients for a longer period to determine whether these associations change. Pre- and post-treatment serum IL10/IL12 and circulating T regs were measured using ELISA and flow cytometry respectively and were correlated with survival after a 33 month average follow-up in a cohort of newly presenting HNSCC patients (n=107), with cancers of the hypopharynx (n=16), larynx (n=36), oral cavity (n=21), oropharynx (n=25), sinonasal (n=4) or unknown origin (n=5). Although the mean survival time of patients with detectable levels of IL10 pre-treatment was lower (40.6 months) than that of those without detectable levels of IL10 (45.6 months), the difference was no longer significant, in contrast to earlier follow-up data. In conclusion, although serum levels of IL10 may be a prognostic indicator for HNSCC patients over the short-term, they become less significant as follow-up time increases.
Green, V. L., Irune, E., Prasai, A., Alhamarneh, O., Greenman, J., & Stafford, N. D. (2012). Serum IL10, IL12 and circulating CD4+CD25high T regulatory cells in relation to long-term clinical outcome in head and neck squamous cell carcinoma patients. International Journal of Oncology, 40(3), 833-839. https://doi.org/10.3892/ijo.2011.1259
|Journal Article Type||Article|
|Acceptance Date||Oct 5, 2011|
|Online Publication Date||Nov 10, 2011|
|Publication Date||Mar 1, 2012|
|Peer Reviewed||Peer Reviewed|
|Keywords||Cancer Research; Oncology|
This file is under embargo due to copyright reasons.
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