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Association of Differing Qatari Genotypes with Vitamin D Metabolites

Dakroury, Youssra


Youssra Dakroury


Stephen Atkin


This work aimed to determine the possible association between Qatari genotypes and vitamin-D deficiency and diabetes complications. Through next-generation exome sequencing three major genetic Qatari genotypes were determined, Q1 - Bedouin, Q2 - Persian-South Asian and Q3 - African. The hypothesis was that Qatari genotypes would affect vitamin D and metabolite levels independent of cultural factors, perhaps exacerbated by diabetes.
Materials and Methods. Affymetrix 500k SNP arrays determined 398 Qataris genotype (mean age 49.8 years, 56.8% male; type 2 diabetes (T2DM) 220; control 178). LC-MS/MS analysis measured 1,25-dihydroxyvitamin-D (1,25(OH)2D), 25-hydroxyvitamin-D2 (25(OH)D2), 25-hydroxyvitamin-D3 (25(OH)D3), 24,25-dihydroxyvitamin-D (24,25(OH)2D) and 25-hydroxy-3epi-Vitamin-D (3epi25(OH)D). The same study population was used to investigate the association of diabetes and its complications with various genotypes.
Results. There was no difference in 25(OH)D levels between genotype groups; however, 1,25(OH)2D was higher for Q2 and 24,25(OH)2D was higher in Q1 compared to the ‘admixed’ group. Additionally, the genotype-based ancestry and type 2 diabetes (T2DM) prevalence: 164 (41.2%) with Q1, 60.4% with T2DM; 149 (37.4%) with Q2, 49.7% with T2DM; 31 (7.8%) with Q3, 61.3% with T2DM; and 54 (13.6%) with “admixed”, 51.9% with T2DM. In patients with diabetes, hypertension (p<0.035) and retinopathy (p<0.016) were greater in Q3.
Conclusion. Overall, the study population was vitamin-D deficient, total 25(OH)D was higher in patients with concomitant T2DM, 1,25(OH)2D, 24,25(OH)2D and 3epi25(OH)D were lower in diabetes. Vitamin D levels were not associated with a specific genotype. Q3 was found to have a higher frequency of diabetic retinopathy and hypertension.


Dakroury, Y. (2020). Association of Differing Qatari Genotypes with Vitamin D Metabolites. (Thesis). Hull York Medical School, The University of Hull and The University of York. Retrieved from

Thesis Type Thesis
Deposit Date Feb 7, 2023
Publicly Available Date Feb 7, 2023
Public URL
Additional Information Hull York Medical School, The University of Hull and The University of York
Award Date 2020-11


Thesis (536 Kb)

Copyright Statement
© 2020 Youssra Dakroury. All rights reserved. No part of this publication may be reproduced without the written permission of the copyright holder.

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