Modulatory properties of curcumin in cancer: A narrative review on the role of interferons

Chamani, Sajjad; Moossavi, Maryam; Naghizadeh, Ali; Abbasifard, Mitra; Kesharwani, Prashant; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

doi:10.1002/ptr.7734

Modulatory properties of curcumin in cancer: A narrative review on the role of interferons

Chamani, Sajjad; Moossavi, Maryam; Naghizadeh, Ali; Abbasifard, Mitra; Kesharwani, Prashant; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Authors

Sajjad Chamani

Maryam Moossavi

Ali Naghizadeh

Mitra Abbasifard

Prashant Kesharwani

Professor Thozhukat Sathyapalan T.Sathyapalan@hull.ac.uk
Professor of Diabetes, Endocrinology and Metabolism

Amirhossein Sahebkar

Abstract

The immune network is an effective network of cell types and chemical compounds established to maintain the body's homeostasis from foreign threats and to prevent the risk of a wide range of diseases; hence, its proper functioning and balance are essential. A dysfunctional immune system can contribute to various disorders, including cancer. Therefore, there has been considerable interest in molecules that can modulate the immune network. Curcumin, the active ingredient of turmeric, is one of these herbal remedies with many beneficial effects, including modulation of immunity. Curcumin is beneficial in managing various chronic inflammatory conditions, improving brain function, lowering cardiovascular disease risk, prevention and management of dementia, and prevention of aging. Several clinical studies have supported this evidence, suggesting curcumin to have an immunomodulatory and anti-inflammatory function; nevertheless, its mechanism of action is still not clear. In the current review, we aim to explore the modulatory function of curcumin through interferons in cancers.

Citation

Chamani, S., Moossavi, M., Naghizadeh, A., Abbasifard, M., Kesharwani, P., Sathyapalan, T., & Sahebkar, A. (in press). Modulatory properties of curcumin in cancer: A narrative review on the role of interferons. Phytotherapy Research, https://doi.org/10.1002/ptr.7734

Journal Article Type	Review
Acceptance Date	Jan 10, 2023
Online Publication Date	Feb 6, 2023
Deposit Date	Feb 18, 2023
Publicly Available Date	Feb 7, 2024
Journal	Phytotherapy Research
Print ISSN	0951-418X
Electronic ISSN	1099-1573
Publisher	Wiley
Peer Reviewed	Peer Reviewed
DOI	https://doi.org/10.1002/ptr.7734
Keywords	Cancer; Curcumin; Immunomodulation; Turmeric
Public URL	https://hull-repository.worktribe.com/output/4202284