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Modulatory properties of curcumin in cancer: A narrative review on the role of interferons

Chamani, Sajjad; Moossavi, Maryam; Naghizadeh, Ali; Abbasifard, Mitra; Kesharwani, Prashant; Sathyapalan, Thozhukat; Sahebkar, Amirhossein


Sajjad Chamani

Maryam Moossavi

Ali Naghizadeh

Mitra Abbasifard

Prashant Kesharwani

Amirhossein Sahebkar


The immune network is an effective network of cell types and chemical compounds established to maintain the body's homeostasis from foreign threats and to prevent the risk of a wide range of diseases; hence, its proper functioning and balance are essential. A dysfunctional immune system can contribute to various disorders, including cancer. Therefore, there has been considerable interest in molecules that can modulate the immune network. Curcumin, the active ingredient of turmeric, is one of these herbal remedies with many beneficial effects, including modulation of immunity. Curcumin is beneficial in managing various chronic inflammatory conditions, improving brain function, lowering cardiovascular disease risk, prevention and management of dementia, and prevention of aging. Several clinical studies have supported this evidence, suggesting curcumin to have an immunomodulatory and anti-inflammatory function; nevertheless, its mechanism of action is still not clear. In the current review, we aim to explore the modulatory function of curcumin through interferons in cancers.


Chamani, S., Moossavi, M., Naghizadeh, A., Abbasifard, M., Kesharwani, P., Sathyapalan, T., & Sahebkar, A. (in press). Modulatory properties of curcumin in cancer: A narrative review on the role of interferons. Phytotherapy Research,

Journal Article Type Review
Acceptance Date Jan 10, 2023
Online Publication Date Feb 6, 2023
Deposit Date Feb 18, 2023
Publicly Available Date Feb 7, 2024
Journal Phytotherapy Research
Print ISSN 0951-418X
Electronic ISSN 1099-1573
Publisher Wiley
Peer Reviewed Peer Reviewed
Keywords Cancer; Curcumin; Immunomodulation; Turmeric
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