Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies

Heidari, Hajar; Bagherniya, Mohammad; Majeed, Muhammed; Sathyapalan, Thozhukat; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

Abstract

Curcumin is extracted from the rhizomes Curcuma longa L. It is known for its anti-inflammatory and anti-oxidant activities. Despite its safety and potential for use against various diseases, curcumin's utility is restricted due to its low oral bioavailability. Co-administration of curcumin along with piperine could potentially improve the bioavailability of curcumin. The present review aimed to provide an overview of the efficacy and safety of curcumin-piperine co-supplementation in human health. The findings of this comprehensive review show the beneficial effects of curcumin-piperine in improving glycemic indices, lipid profile and antioxidant status in diabetes, improving the inflammatory status caused by obesity and metabolic syndrome, reducing oxidative stress and depression in chronic stress and neurological disorders, also improving chronic respiratory diseases, asthma and COVID-19. Further high-quality clinical trial studies are needed to firmly establish the clinical efficacy of the curcumin-piperine supplement.

Citation

Heidari, H., Bagherniya, M., Majeed, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (in press). Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies. Phytotherapy Research, https://doi.org/10.1002/ptr.7737

• Journal Article Type: Review
• Acceptance Date: Jan 9, 2023
• Online Publication Date: Jan 31, 2023
• Deposit Date: Feb 18, 2023
• Publicly Available Date: Feb 1, 2024
• Journal: Phytotherapy Research
• Print ISSN: 0951-418X
• Electronic ISSN: 1099-1573
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1002/ptr.7737
• Keywords: Clinical; Curcumin; Health; Piperine; Preclinical
• Public URL: https://hull-repository.worktribe.com/output/4202294