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Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies

Heidari, Hajar; Bagherniya, Mohammad; Majeed, Muhammed; Sathyapalan, Thozhukat; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

Authors

Hajar Heidari

Mohammad Bagherniya

Muhammed Majeed

Tannaz Jamialahmadi

Amirhossein Sahebkar



Abstract

Curcumin is extracted from the rhizomes Curcuma longa L. It is known for its anti-inflammatory and anti-oxidant activities. Despite its safety and potential for use against various diseases, curcumin's utility is restricted due to its low oral bioavailability. Co-administration of curcumin along with piperine could potentially improve the bioavailability of curcumin. The present review aimed to provide an overview of the efficacy and safety of curcumin-piperine co-supplementation in human health. The findings of this comprehensive review show the beneficial effects of curcumin-piperine in improving glycemic indices, lipid profile and antioxidant status in diabetes, improving the inflammatory status caused by obesity and metabolic syndrome, reducing oxidative stress and depression in chronic stress and neurological disorders, also improving chronic respiratory diseases, asthma and COVID-19. Further high-quality clinical trial studies are needed to firmly establish the clinical efficacy of the curcumin-piperine supplement.

Citation

Heidari, H., Bagherniya, M., Majeed, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (in press). Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies. Phytotherapy Research, https://doi.org/10.1002/ptr.7737

Journal Article Type Review
Acceptance Date Jan 9, 2023
Online Publication Date Jan 31, 2023
Deposit Date Feb 18, 2023
Publicly Available Date Mar 28, 2024
Journal Phytotherapy Research
Print ISSN 0951-418X
Electronic ISSN 1099-1573
Publisher Wiley
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1002/ptr.7737
Keywords Clinical; Curcumin; Health; Piperine; Preclinical
Public URL https://hull-repository.worktribe.com/output/4202294

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