The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling

Xiao, Yu Pei

Abstract

Proteinase-activated receptors (PARs) are a novel family of G-protein coupled receptors (GPCRs) that mediate many of the diverse biological effects of proteinases on target cells. N-linked glycosylation is a common post-translational modification in the GPCR superfamily that enables the cell to regulate protein function without recourse to the genome. Previous pharmacological studies have found that activation of hPAR-2 by mast cell tryptase can be regulated by receptor N-terminal glycosylation. However, the role of N-linked glycosylation in regulating the expression and function of other PARs is not known.

Citation

Xiao, Y. P. (2008). The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4208901

• Thesis Type: Thesis
• Deposit Date: Aug 16, 2011
• Publicly Available Date: Feb 22, 2023
• Keywords: Medicine
• Public URL: https://hull-repository.worktribe.com/output/4208901
• Additional Information: Department of Cardiovascular Respiratory Medicine, Postgraduate Medical Institute, The University of Hull
• Award Date: Apr 1, 2008