Yu Pei Xiao
The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling
Xiao, Yu Pei
Authors
Contributors
Steven J. Compton
Supervisor
Alyn H. Morice
Supervisor
Abstract
Proteinase-activated receptors (PARs) are a novel family of G-protein coupled receptors (GPCRs) that mediate many of the diverse biological effects of proteinases on target cells. N-linked glycosylation is a common post-translational modification in the GPCR superfamily that enables the cell to regulate protein function without recourse to the genome. Previous pharmacological studies have found that activation of hPAR-2 by mast cell tryptase can be regulated by receptor N-terminal glycosylation. However, the role of N-linked glycosylation in regulating the expression and function of other PARs is not known.
Citation
Xiao, Y. P. (2008). The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4208901
Thesis Type | Thesis |
---|---|
Deposit Date | Aug 16, 2011 |
Publicly Available Date | Feb 22, 2023 |
Keywords | Medicine |
Public URL | https://hull-repository.worktribe.com/output/4208901 |
Additional Information | Department of Cardiovascular Respiratory Medicine, Postgraduate Medical Institute, The University of Hull |
Award Date | Apr 1, 2008 |
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Thesis
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Copyright Statement
© 2008 Xiao, Yu Pei. All rights reserved. No part of this publication may be reproduced without the written permission of the copyright holder.
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