Skip to main content

Research Repository

Advanced Search

The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling

Xiao, Yu Pei

Authors

Yu Pei Xiao



Contributors

Steven J. Compton
Supervisor

Alyn H. Morice
Supervisor

Abstract

Proteinase-activated receptors (PARs) are a novel family of G-protein coupled receptors (GPCRs) that mediate many of the diverse biological effects of proteinases on target cells. N-linked glycosylation is a common post-translational modification in the GPCR superfamily that enables the cell to regulate protein function without recourse to the genome. Previous pharmacological studies have found that activation of hPAR-2 by mast cell tryptase can be regulated by receptor N-terminal glycosylation. However, the role of N-linked glycosylation in regulating the expression and function of other PARs is not known.

Citation

Xiao, Y. P. (2008). The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4208901

Thesis Type Thesis
Deposit Date Aug 16, 2011
Publicly Available Date Feb 22, 2023
Keywords Medicine
Public URL https://hull-repository.worktribe.com/output/4208901
Additional Information Department of Cardiovascular Respiratory Medicine, Postgraduate Medical Institute, The University of Hull
Award Date Apr 1, 2008

Files

Thesis (4.3 Mb)
PDF

Copyright Statement
© 2008 Xiao, Yu Pei. All rights reserved. No part of this publication may be reproduced without the written permission of the copyright holder.




Downloadable Citations