Synthesis of new calixarene-based scandium precursors for medical imaging

Alamri, Mohammed Abdulhadi R.

Abstract

Targeted radionuclide therapy is a new and an effective approach for cancer imaging and therapy complementary to the existing methods. In the last decade, the use of metal complexes in imaging and therapy has gained commonality in most clinical situations. The development of 99mTc radiopharmaceuticals initiated the coordination chemistry studies as it relates to diagnostic imaging. Currently, there are many types of radio metal complexes used in PET and gamma scintigraphy.
Scandium, of all the emitters, is an innovative element for Nuclear Medicine and has attracted attention as a prospective radionuclide for PET imaging. It has an isotope appropriate for targeted radionuclide therapy (Scandium 47) as well as for imaging by PET (Scandium 44). Lately, scandium isotopes (47Sc, 44Sc) are readily obtainable and their qualities are suitable for PET imaging or radiotherapy.
Furthermore, Calixarenes have the capacity to complex a variety of molecules in aqueous phase, which is fascinating for biological application. The facile functionalization of calixarenes at the lower or upper rim, allows for readily adjustable properties, viz solubility, emission and biological recognition.In this project, we tried to exploit the properties of both scandium and calixarenes and use the calixarenes as a scaffold to investigate their potential to transport a scandium radiolabel. We focused on the synthesis of new scandium calixarene complexes as precursors for medical imaging. We synthesised four new scandium-calixarene complexes.

Citation

Alamri, M. A. R. (2018). Synthesis of new calixarene-based scandium precursors for medical imaging. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222917

• Thesis Type: Thesis
• Deposit Date: Mar 10, 2021
• Publicly Available Date: Feb 23, 2023
• Keywords: Chemistry
• Public URL: https://hull-repository.worktribe.com/output/4222917
• Additional Information: Department of Chemistry, The University of Hull
• Award Date: Dec 1, 2018