Improved control strategies for the environment within cell culture bioreactors

Jones, Jonathan; Kindembe, Didier; Branton, Harvey; Lawal, Najib; Montero, Eduardo Lopez; Mack, John; Shi, Shuo; Patton, Ron; Montague, Gary

Abstract

This paper describes the development of improved control strategies for the standard environmental conditions in a fed-batch bioreactor used for monoclonal antibody cell culture. The consequences of relying on fixed parameter PID based controllers are considered and poor performance is demonstrated as a consequence of non-linearity and loop interactions. The benefits from adopting a more sophisticated control strategy are considered. Model Predictive Control (MPC) relies on a process model that can be identified from small system perturbations. It considers the predicted longer-term response and consequently can deliver improved control and satisfy user defined constraints. Results from experimental trials demonstrate the capability of MPC and the merits are discussed with regards to industrial application.

Citation

Jones, J., Kindembe, D., Branton, H., Lawal, N., Montero, E. L., Mack, J., …Montague, G. (2023). Improved control strategies for the environment within cell culture bioreactors. Food and Bioproducts Processing, 138, 209-220. https://doi.org/10.1016/j.fbp.2023.02.004

• Journal Article Type: Article
• Acceptance Date: Feb 8, 2023
• Online Publication Date: Feb 16, 2023
• Publication Date: 2023-03
• Deposit Date: Feb 24, 2023
• Publicly Available Date: Mar 2, 2023
• Journal: Food and Bioproducts Processing
• Print ISSN: 0960-3085
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 138
• Pages: 209-220
• DOI: https://doi.org/10.1016/j.fbp.2023.02.004
• Keywords: Cell culture; Predictive control; Environment; Monoclonal antibodies
• Public URL: https://hull-repository.worktribe.com/output/4224900