Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: A cardiovascular magnetic resonance study

Bourantas, Christos V.; Nikitin, Nikolay P.; Loh, Huan P.; Lukaschuk, Elena I.; Tweddel, Ann C.; Alamgir, Mohamed F.; Clark, Andrew L.; Cleland, John G F; Cleland, John G. F.; Bourantas, Christos V; Nikitin, Nikolay P; Loh, Huan P; Lukaschuk, Elena I; Sherwi, Nassar; de Silva, Ramesh; Tweddel, Ann C; Alamgir, Mohamed F; Wong, Kenneth; Gupta, Sanjay; Clark, Andrew L; Cleland, John GF

Abstract

BackgroundCardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) can provide unique data on the transmural extent of scar/viability. We assessed the prevalence of dysfunctional myocardium, including partial thickness scar, which could contribute to left ventricular contractile dysfunction in patients with heart failure and ischaemic heart disease who denied angina symptoms. MethodsWe invited patients with ischaemic heart disease and a left ventricular ejection fraction < 50% by echocardiography to have LGE CMR. Myocardial contractility and transmural extent of scar were assessed using a 17-segment model. ResultsThe median age of the 193 patients enrolled was 70 (interquartile range: 63-76) years and 167 (87%) were men. Of 3281 myocardial segments assessed, 1759 (54%) were dysfunctional, of which 581 (33%) showed no scar, 623 (35%) had scar affecting ≤50% of wall thickness and 555 (32%) had scar affecting > 50% of wall thickness. Of 1522 segments with normal contractile function, only 98 (6%) had evidence of scar on CMR. Overall, 182 (94%) patients had ≥1 and 107 (55%) patients had ≥5 segments with contractile dysfunction that had no scar or ≤50% transmural scar suggesting viability. ConclusionsIn this cohort of patients with left ventricular systolic dysfunction and ischaemic heart disease, about half of all segments had contractile dysfunction but only one third of these had > 50% of the wall thickness affected by scar, suggesting that most dysfunctional segments could improve in response to an appropriate intervention.

Citation

Bourantas, C. V., Nikitin, N. P., Loh, H. P., Lukaschuk, E. I., Sherwi, N., de Silva, R., Tweddel, A. C., Alamgir, M. F., Wong, K., Gupta, S., Clark, A. L., & Cleland, J. G. (2011). Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: A cardiovascular magnetic resonance study. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 13(53), Article ARTN 53. https://doi.org/10.1186/1532-429x-13-53

• Journal Article Type: Article
• Acceptance Date: Sep 21, 2011
• Online Publication Date: Sep 21, 2011
• Publication Date: Sep 21, 2011
• Journal: JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
• Print ISSN: 1097-6647
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 53
• Article Number: ARTN 53
• DOI: https://doi.org/10.1186/1532-429x-13-53
• Keywords: Heart failure; Myocardial infarction; Hibernation; Cardiovascular magnetic resonance imaging; Late gadolinium enhancement
• Public URL: https://hull-repository.worktribe.com/output/423574